Nrf2 and Oxidative Stress: A General Overview of Mechanisms and ...
Upon oxidative stress, sensor cysteines in Keap1 are modified by ROS, leading to Nrf2 stabilization, accumulation, and translocation to the nucleus where Nrf2 heterodimerizes with …
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in ...
Accumulating evidence has shown that mitochondrial ROS (mtROS) activate Nrf2, often mediated by certain protein kinases, and induce the expression of antioxidant genes and genes involved …
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in ...
Feb 17, 2020 · Accumulating evidence has shown that mitochondrial ROS (mtROS) activate Nrf2, often mediated by certain protein kinases, and induce the expression of antioxidant genes and …
Nrf2 regulates ROS production by mitochondria and NADPH …
We here show that ROS production in Nrf2-KO cells and tissues is increased compared to their WT counterparts. Mitochondrial ROS production is regulated by the Keap1–Nrf2 pathway by …
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and ...
Nov 27, 2022 · This review aims to provide the reader with a general overview of oxidative stress and Nrf2, including basic mechanisms of Nrf2 activation and regulation, and implications in …
The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis …
Jan 1, 2020 · Our data show that ROS, KRAS and Nrf2 form a molecular axis preventing ROS accumulation to toxic levels that could inhibit proliferation. We also found that the …
Targeting ROS-sensing Nrf2 potentiates anti-tumor immunity of ...
Nov 6, 2024 · ROS-sensing Nrf2 inhibits the anti-tumor T cell responses, indicating that Nrf2 may be a potential target for T cell immunotherapy strategies against solid tumors.
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in …
Feb 17, 2020 · Accumulating evidence has shown that mitochondrial ROS (mtROS) activate Nrf2, often mediated by certain protein kinases, and induce the expression of antioxidant genes and …
A Salidroside‐Based Radiosensitizer Regulates the Nrf2/ROS …
Apr 8, 2025 · After X-ray irradiation, salidroside inhibits the Nuclear factor erythroid 2-like 2 (Nrf2)protein expression and blocks cells in the G2/M phase with the highest radiosensitivity, …
Cell-based Assays to Identify Modulators of Nrf2/ARE Pathway
The induction of many cytoprotective enzymes in response to ROS is mediated by antioxidant response elements (ARE), which activate the nuclear factor erythroid 2-related factor (Nrf2). …
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