NOX1 deficiency plus TNFα stimulation contribute to colitis through dysregulation of the stem cell niche and altered cell differentiation, enhancing basal lymphoplasmacytosis. Our findings prioritise ROS modulation for future therapies.

NOX1 is expressed in pancreatic β-cells and plays an important role for ROS production during glucose-stimulated insulin secretion . A further connection between the glucose-sensing mechanism and NOX1 is observed in C2C12 cells that show a NOX1-dependent glucose sensing pathway for selective phosphorylation of p70S6k.

Jun 1, 2021 · The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first identified in the membrane of phagocytic cells. For many years, its only known role was in immune defense, where its ROS production leads to the destruction of …

Oct 22, 2024 · In this study, we explore the role of NOX1 and ROS through direct ex vivo studies of single cell UC transcriptomics (scRNAseq) and in vitro and in vivo murine studies. We show that under a variety of colonoid differentiation conditions, TNFα induced ROS secretion is dependent upon NOX1.

Dec 6, 2017 · Reactive oxygen species (ROS) are well characterized as part of the innate phagocytic immunity; however, a role in controlling microorganisms in the gut lumen is less clear. Here, we show a...

Together with the phagocyte NADPH oxidase itself (NOX2/gp91(phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

Sep 14, 2024 · The formation of reactive oxygen species (ROS) by Nox1, NoxA1, and NoxO1 can result in alterations to a cellular phenotype. It is possible that NoxO1 exerts pro-survival effects in cancer cells.

Oct 2, 2018 · Here, we investigated whether NOX1 activation and ROS production induced by key inflammatory cytokines in IBD causally affects LCN-2 production in colonic epithelial cells.

Feb 15, 2016 · The results suggest that Nox1 is indeed responsible for ROS generation in the colon epithelial cells and exerts its biological role through ROS signaling. Furthermore, both the Nox1 level (Fig. 3B) and Ki-67-positive cells (Fig. 3C) significantly increased in DSS-treated WT mice compared with untreated controls during the recovery period ...

Feb 2, 2021 · Reactive oxygen species (ROS) produced by NADPH1 oxidase 1 (NOX1) are thought to drive spermatogonial stem cell (SSC) self-renewal through feed-forward production of ROS by the ROS-BCL6B-NOX1 pathway. Here we report the critical role of oxygen on ROS-induced self-renewal.