Sep 15, 2004 · Studies from several independent groups suggest that ROS converge on the matrix metalloproteinase family members by regulating both MMP gene expression and MMP …

In this chapter, we describe a relation between mitochondrial membrane potential and the rate of ROS formation. We present different methods applicable for isolated mitochondria or intact cells.

Jul 20, 2020 · We propose a model where macrophage recruitment to and activation at overgrowing tissue is a multi-step process requiring ROS- and JNK-mediated Mmp2 …

Oct 3, 2018 · Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated …

Here, we report a molecular axis, comprising the molecular adaptor hydrogen peroxide-inducible clone-5 (HIC-5), NADPH oxidase 4 (NOX4), and mitochondria-associated reactive oxygen …

Dec 12, 2010 · ROS can activate upstream kinases (MKK) responsible for MAPK activation and restrict the activity of their inhibitory phosphatases. Here we focus on the redox-sensitive …

Jun 1, 2016 · In most models, ROS and mitochondrial Ca 2 + cooperate to induce MMP. ROS directly target several components involved in MMP. However, the mechanisms by which …

Aug 14, 2017 · Here we summarized the nuclear localization mechanisms of MMPs and their functions in the nucleus such as apoptosis, tissue remodeling upon injury and cancer …

Apr 1, 2006 · ROS regulate MMP gene expression and activation of proenzymes. MMP-1, MMP-2, MMP-7, and MMP-9 are activated by ROS through interactions with thiol groups, in which …

Jan 16, 2025 · The resulting nanocomposite hydrogel (si-Fe-HPP) synergizes the therapeutic effects of MMP-13 gene silencing and ROS scavenging to suppress joint inflammation and …