Mar 1, 2021 · By using antioxidants N-acetylcysteine and catalase, we found that ERK pathway was activated by a reactive oxygen species- (ROS-) dependent mechanism after exposure to …

Jan 13, 2021 · Our data demonstrate new relationships between regeneration-related ROS production and MAPK/ERK activation at the earliest regeneration stages, as well as the …

Activated ERK1/2 phosphorylates RSK and both RSK and ERK translocate to the nucleus where they activates multiple transcription factors ultimately resulting in effector protein synthesis and …

Jun 23, 2020 · We then systematically discuss how ERK signalling regulates six fundamental cellular processes in response to extracellular cues.

Feb 1, 2024 · Reactive oxygen species (ROS) activate JNK, p38 and ERK mitogen-activated protein kinases (MAPK), which upregulate c-Jun and c-Fos expression at the transcriptional …

Dec 4, 2021 · Studies have confirmed that higher concentrations of ROS leads to autophagy or cell death. In this research, the role of CC90003-induced ROS was verified. But after inhibiting …

ROS and the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway were inhibited to detect the MAPK/ERK pathway, nuclear factor erythroid …

ROS-mediated ERK signaling activation may constitute an underlying mechanism functionally connecting apoptosis and autophagy since the NAC treatment canceled both types of cell …

Mar 2, 2021 · Urinary protein-induced ROS production triggers a cascade of phosphorylation reactions in the ERK pathway, which is a common mediator of protective autophagy and injury …

Although ROS have been suggested to have an important role in sustaining MAPK signaling, antioxidant treatment increased ERK phosphorylation, probably suggesting increased invasive …