Hyperglycemic states aid in increasing ROS production through several mechanisms—uncoupling of eNOS, NOX activation, and the impairment of the pentose phosphate pathway, which …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic …

Taken together, we demonstrate, for the first time, that Ang II upregulates nNOS protein expression and activity via AT1R/ROS/eNOS-dependent S-nitrosation and membrane …

Mar 9, 2023 · Here, we discuss the main mechanisms of eNOS uncoupling, including oxidative depletion of the critical eNOS cofactor BH 4, deficiency of eNOS substrate L-Arg, or …

Feb 17, 2017 · Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine …

Oct 7, 2019 · NADPH oxidase (NOX)-derived reactive oxygen species (ROS) production induces endothelial nitric oxide synthase (eNOS) uncoupling and mitochondrial dysfunction, resulting in …

Apr 21, 2011 · Reactive oxygen species (ROS) may directly alter vascular function or cause changes in vascular tone by several mechanisms including altered nitric oxide (NO) …

Many lines of evidence indicate that oxidative degeneration of BH 4 by ROS leads to the eNOS uncoupling, reduction in NO bioavailability, and increased reactive oxygen species production …

Mar 16, 2018 · In addition to NOX-dependent ROS production, the nitric oxide synthases (eNOS [endothelial], nNOS [neuronal], and iNOS [inducible]) are sources of cytoROS. eNOS …

not only is superoxide formed by activated NADPH oxidase, but eNOS also has the potential to generate ROS. In fact eNOS may produce both NO, via its oxygenase function, and …