Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion.

von Willebrand factor (VWF) is an adhesive and multimeric glycoprotein that found its historical origin in 1924, when the Finnish physician Erik von Willebrand first reported a family with a serious hereditary bleeding affecting consanguineous families 1. The proband was a five years old girl with severe bleeding since birth.

Feb 20, 2023 · Von Willebrand factor (vWF) is a glycoprotein crucial to primary hemostasis through platelet and subendothelial collagen adhesion and the intrinsic coagulation cascade through factor VIII stabilization.

Recent studies highlight the involvement of VWF and its regulator, ADAMTS13, in mechanisms that underlie vascular inflammation and immunothrombosis, like leukocyte rolling, adhesion, and extravasation; vascular permeability; ischemia/reperfusion injury; …

Feb 5, 2025 · Using endothelialized fluidic devices, we show that aberrant flow patterns that may occur in venous valve pockets of individuals with common stasis-related risk factors can cause the formation of von Willebrand factor–platelet tangles that are resistant to ADAMTS13 removal.

Von Willebrand factor (vWF) is an adhesive, multimeric glycoprotein present in plasma, platelets, and subendothelium, which has two main functions: (1) it serves as a carrier for factor VIII and (2) it plays a crucial role in platelet adhesion to subendothelium, acting as a “bridge” between platelet membrane glycoprotein (GP) Ib and GP IIb ...

Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that plays a central role in the initiation of blood coagulation. Through interactions between its specific functional domains, the vascular wall, coagulation factor VIII, and platelet ...

Aug 1, 2024 · Von Willebrand factor (VWF) is a protein crucial to the blood clotting process. If you don’t have enough of this protein, or if it doesn’t work as it’s supposed to, you may have von...

von Willebrand factor (vWF, or VWF), glycoprotein that plays an important role in stopping the escape of blood from vessels (hemostasis) following vascular injury. Von Willebrand factor (VWF) works by mediating the adherence of platelets to one another and to sites of vascular damage.

Mar 18, 2008 · von Willebrand factor (VWF) plays a pivotal role in platelet adhesion and aggregation at sites of high shear rates (eg, in coronary arteries that have stenotic or ruptured atherosclerotic plaque lesions). Numerous studies have investigated the relationship between VWF plasma levels and thromboembolic cardiovascular events.