
Glucocorticoid Receptor α Mediates Roflumilast’s Ability to …
Jan 14, 2020 · Rofl inhibits IL-8 and TNFα production in COPD HBE cells additively with Dex in a GRα-dependent manner. (A-B) COPD HBE cells were treated with Rofl, Dex, or combined Rofl and Dex at indicated concentrations for 6 h.
Glucocorticoid Receptor α Mediates Roflumilast’s Ability to …
Jan 14, 2020 · Rofl Inhibits IL-8 and TNFα Production in COPD HBE Cells Additively with Dex in a GRα-Dependent Manner. Decreased cytokine and chemokine secretion is a key mechanism contributing to the anti-inflammatory actions of both Rofl and Dex.
Glucocorticoid Receptor α Mediates Roflumilast’s Ability t | COPD
Sep 7, 2019 · These findings show that increased GRα expression can reverse glucocorticoid resistance and also clearly reveal a new mechanistic basis of Rofl’s therapeutic actions in COPD, 15,16,27 as GRα knockdown blocked the cytokine-inhibitory action of Rofl combined with Dex.
(PDF) Glucocorticoid Receptor α Mediates Roflumilast’s Ability to ...
Rofl inhibits IL-8 and TNFα production in COPD HBE cells additively with Dex in a GRα-dependent manner. (A-B) COPD HBE cells were treated with Rofl, Dex, or combined Rofl and Dex at...
Rofl inhibits IL-8 and TNFα production in COPD HBE cells …
Rofl and Dex gave greater suppression of IL-8 ( Figure 4 A) and TNFα ( Figure 4 B) release than either drug alone.
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