RNF proteins orchestrate the cGAS-STING signaling pathway. Upon activation by dsDNA, cytosolic cGAS triggers STING activation and translocation through synthesizing cGAMP, consequently inducing IFN-I and inflammatory cytokines production. RNF proteins can target multiple steps in the DNA sensing signal pathway.

Dec 9, 2011 · In humans, 49 RNF proteins are predicted to contain transmembrane domains, several of which are specifically localized to membrane compartments in the secretory and endocytic pathways, as well as to mitochondria and peroxisomes.

In this review, we summarize the current understanding of both classical and nonclassical functions of RNF8, and discuss its roles in the pathogenesis and progression of tumor. Keywords: RNF8, DSB, telomere, cell cycle, transcriptional regulation, tumor.

Feb 9, 2022 · Increasing evidence has demonstrated that RING finger (RNF) proteins played a vital role in cellular and physiological processes and various diseases. However, the function of RNF proteins in low-grade glioma (LGG) remains unknown. In this study, 138 RNF family members revealed their role in LGG.

Fno/Rnf couples the flow of electrons from reduced ferredoxin (Fd red) to NAD + thereby generating a sodium ion gradient across the cytoplasmic membrane. For explanations, see text. ox oxidized, red reduced. A membrane-bound, Na + -translocating ferredoxin:NAD + oxidoreductase, the Rnf complex.

Nov 20, 2023 · RNF13 is involved in the process of anti-oxidative stress in cardiac hypertrophy. p62-NRF2 signaling pathway is necessary for RNF13 to regulate the cardiac hypertrophy. Heart failure (HF) severely impairs human health because of its high incidence and mortality.

Mar 30, 2025 · RNF6 (Ring Finger Protein 6) is a Protein Coding gene. Diseases associated with RNF6 include Esophageal Cancer and Esophagus Squamous Cell Carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and …

May 22, 2013 · The reason they're labeled RNF and not GND, is that often times you will see a low value (e.g., under an ohm) resistor inserted in that return path. The resistor provides a voltage drop proportional to the current the bridge is passing.

Oct 10, 2018 · The Rnf complex is a respiratory enzyme that catalyzes the oxidation of reduced ferredoxin to the reduction of NAD + , and the negative free energy change of this reaction is used to generate a transmembrane ion gradient.

Jun 18, 2024 · Here we report the cryogenic electron microscopy structure of the nitrogenase-associated RNF complex of A. vinelandii, a seven-subunit membrane protein assembly that contains four flavin...