Glaucoma is generally described as a loss of retinal ganglion cell axons. This loss is routinely diagnosed by the presence of thinning of the optic nerve neuroretinal rim, peripapillary retinal nerve fiber layer (RNFL), and/or inner layers of the macula.

The retinal nerve fiber layer (RNFL) or nerve fiber layer, stratum opticum, is part of the anatomy of the eye. The RNFL formed by the expansion of the fibers of the optic nerve; it is thickest near the optic disc, gradually diminishing toward the ora serrata.

Wedge shaped thinning of the retinal nerve fiber layer (RNFL; red zones in the RNFL Deviation Map) are evident in the superior and inferior regions in the right eye. RNFL Thickness profile also demonstrates localized thinning in the same regions.

Oct 31, 2018 · They hypothesized that the degree of vessel density may predict RNFL thinning of eyes with mild or moderate glaucoma. Their findings suggest that lower macular and ONH vessel density are associated with faster RNFL decline, as measured by spectral-domain optical coherence tomography (SD-OCT).

Recently, techniques utilizing sophisticated laser scanning with digital image processing have been used to assist clinical evaluation of the optic nerve and the retinal nerve fiber layer (RNFL).

An eye with slow rate of RNFL loss (stable eye, left panel) shows higher predicted probability of survival compared with an eye with faster rate of RNFL loss. Table 4. Results of the joint longitudinal survival model (N=454) investigating the effect of retinal nerve fiber layer slope on the risk of development of visual field damage, while ...

Aug 1, 2024 · By measuring thinning in the retinal nerve fiber layer (RNFL), OCT has proved to be effective in helping to diagnose glaucoma. However, OCT can give misleading measurements, known as artifacts.

Examination of retinal nerve fiber layer (RNFL) defects and monitoring of their progression are key components in glaucoma management.

Recall that it is the axons of the ganglion cells that conglomerate at the optic disc to form the neuroretinal rim (NRR) tissue. The utility of RNFL as a surrogate measure for Glaucomatous Optic Neuropathy has been well proven in clinical research. « Where Is the RNFL Measured?

Feb 4, 2023 · To apply retinal nerve fiber layer (RNFL) optical texture analysis (ROTA) to investigate the prevalence, patterns, and risk factors of RNFL defects in patients with ocular hypertension (OHT) who showed normal optic disc and RNFL configuration in clinical examination, normal RNFL thickness on OCT analysis, and normal visual field (VF) results.