Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN) -induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export. [5][6] RNase L is an enzyme that in humans is encod...

2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens.

RNase-L is a mediator of type 1 interferon-induced antiviral activity that has diverse and critical cellular roles, including the regulation of cell proliferation, differentiation, senescence and apoptosis, tumorigenesis, and the control of the innate immune response.

RNase L is a highly regulated, latent endoribonuclease (hence the “L” in RNase L) first cloned in 1993 when it was referred to as the 2-5A-dependent RNase (Zhou and others 1993).

The interferon (IFN)-regulated endoribonuclease RNase-L is involved in multiple aspects of the antimicrobial innate immune response. It is the terminal component of an RNA cleavage pathway in which dsRNA induces the production of RNase-L …

Mar 26, 2025 · Title: Carriage of mutations R462Q (rs 486907) and D541E (rs 627928) of the RNASEL gene and risk factors in patients with prostate cancer in Burkina Faso. OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.

RNASEL is an endoribonuclease that plays a critical role in the interferon (IFN)-mediated antiviral response. In cells treated with IFN or infected with viruses, RNASEL exerts its antiviral effects through a variety of mechanisms, including: Direct cleavage of single-stranded viral RNAs; Inhibition of protein synthesis by degrading rRNA

Oct 1, 2014 · RNase L is a well-known effector of the type I interferon pathway. This review focuses on the recent developments of RNase L activation and on the antagonism of the OAS-RNase L pathway by viral proteins.

May 22, 2005 · RNase L is an endoribonuclease that requires 2′-5′ oligoadenylates to cleave single-stranded RNA. In this report we present evidence demonstrating a role for RNase L in translation. We identify...

20-50oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens.