- Rif is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases. [1] It is primarily active in the brain and plays a physiological role in the formation of neuronal dendritic spine.Learn more:Rif is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases. [1] It is primarily active in the brain and plays a physiological role in the formation of neuronal dendritic spine.en.wikipedia.org/wiki/Rif_(GTPase)The small GTPase Rif is required for the early stages of dendritic spine formation in neurons, acting through the formin mDia2 to control actin polymerization. Rif is expressed at high levels in the brain, suggesting broader roles in neuronal function.www.sciencedirect.com/science/article/pii/S030439…Different from Cdc42, Rif is a fast-cycling atypical small GTPase that exists in a constitutively active, GTP-bound form in cells (11). It induces filopodia on the peripheral and dorsal cell surfaces through its effector mDia2, whereas Cdc42 primarily induces peripheral filopodia (12).www.jbc.org/article/S0021-9258(23)02276-7/fulltext
Rif (GTPase) - Wikipedia
Rif is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases. [1] It is primarily active in the brain and plays a physiological role in …
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The RHO Family GTPases: Mechanisms of Regulation and Signaling
Identified and structurally verified hotspots as functional determinants specific to RHO GTPase regulation by GDIs, GEFs, and GAPs as well as signaling through effectors are presented, and …
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Platelet Rho GTPases–a focus on novel players, roles and …
This review summarizes our understanding of the roles of platelet Rho GTPases and focuses particularly on the functions of Rif and RhoG. In human platelets, Rif interacts with …
The novel Rho-family GTPase Rif regulates coordinated …
Nov 1, 2000 · We have isolated a new Rho-family GTPase, Rif (Rho in filopodia), and shown that it represents an alternative signalling route to the generation …
- Author: Sara Ellis, Harry Mellor
- Publish Year: 2000
Pattern recognition receptor mediated innate immune response …
Small GTPases play critical roles in cell morphology, movement, and adhesion by dynamic regulation of actin cytoskeleton. The small Rho GTPase Rif/RhoF (Rho in filopodia) regulates …
Neurotrophin Promotes Neurite Outgrowth by Inhibiting Rif …
We found that, in PC12 cells, neurotrophin promoted neurite outgrowth partially by inhibiting Rif GTPase activation downstream of MAPK and PI3K signaling. Hence, Rif played a pivotal role …
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The small Rho GTPase Rif and actin cytoskeletal remodelling
The Rif GTPase is a recent addition to small Rho GTPase family; it shares low homology with other members in the family and evolutionarily parallels with the development of vertebrates. …
Rho family small GTPase Rif regulates Wnt5a-Ror1 …
Rho in filopodia (Rif), a member of the Rho family of small GTPases, induces filopodia formation primarily on the dorsal surface of cells; however, its function remains largely unclear. Here, we show that Rif interacts with Ror1, a receptor …
The Rif GTPase regulates cytoskeletal signaling from plexinA4 to ...
Mar 17, 2015 · The small GTPase Rif is required for the early stages of dendritic spine formation in neurons, acting through the formin mDia2 to control actin polymerization. Rif is expressed at …
The small GTPase Rif is an alternative trigger for the formation of ...
Apr 15, 2010 · Here, we show that the Rif GTPase is an alternative trigger of stress-fiber formation in epithelial cells. Rif is distantly related to RhoA; however, we show that the two …
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