RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein , and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins [5] and is …

Mar 30, 2025 · RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Familial Hemophagocytic Lymphohistiocytosis 5 and Lymphoproliferative Syndrome, X-Linked, 2. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and Signaling by Rho GTPases.

Jun 28, 2023 · However, RhoG is known for regulating cellular signaling, gene transcription, and other processes that contribute to immunological diseases and abnormalities [8,9,10]. RhoG was first identified as a RNA sequence induced in the late G1 phase of the cell cycle in serum-treated CCL39 fibroblasts.

The RhoGEF Trio contains two GEF domains that differentially activate the small GTPases such as Rac1/RhoG and RhoA. These ... Many cellular processes are controlled by small GTPases, which can be activated by guanine nucleotide exchange factors (GEFs).

Feb 8, 2025 · RhoG protects cells from apoptosis caused by the loss of anchorage through a PI3K-dependent mechanism, independent of its activation of Rac1. C-terminal basic tail of RhoG specifically assists the recruitment of the TrioN-PH domain …

Jun 28, 2023 · This review focuses on the cellular functions of RhoG, interconnecting different signaling pathways, and speculates the importance of this small GTPase as a prospective target against several pathological conditions.

We propose that biallelic RHOG mutations abrogating its expression specifically impair exocytosis in cytotoxic lymphocytes and ultimately result in FHL. Based on the current FHL classification, 25 RHOG mutations may

RhoG is a member of the Rho family of GTPases that shares 72% and 62% sequence identity with Rac1 and Cdc42Hs, respectively. We have expressed mutant RhoG proteins fused to the green fluorescent protein and analyzed subsequent changes in cell ...

Jan 22, 2003 · RhoG, a member of the Rho family of GTPases, has been implicated as a regulator of the actin cytoskeleton.

RhoG (CAAX = CILL) has the highest sequence similarity to Rac1 (72%) and Cdc42 (62%) and also shares activators, effectors, and biological functions with these proteins [88]. Unlike Rac1, RhoG may be phosphorylated in its hypervariable domain. PKA was capable of phosphorylating RhoG, but not RhoG S187A, in vitro [66]. However, it is unknown if ...