Sep 13, 2007 · Differential Protonation at the Catalytic Six-Iron Cofactor of [FeFe]-Hydrogenases Revealed by 57Fe Nuclear Resonance X-ray Scattering and Quantum Mechanics/Molecular Mechanics Analyses.

Chem Rev. 2009 Jun;109 (6):2245-74. doi: 10.1021/cr800542q. 1 Laboratoire d'Electrochimie Moléculaire, Unité Mixte de Recherche Université-CNRS 7591, Université Paris Diderot, 75013 Paris, France.

Jun 1, 2015 · The [FeFe]- and [NiFe]-hydrogenases catalyze the formal interconversion between hydrogen and protons and electrons, possess characteristic non-protein ligands at their catalytic sites and thus share common mechanistic features.

Nature uses multinuclear metal clusters to catalyse a number of important multielectron redox reactions. Examples that employ complex Fe-S clusters in catalysis include the Fe-Mo cofactor (FeMoco) of nitrogenase and its V and all-Fe variants, and the [FeFe] and [NiFe] hydrogenases.

Dec 15, 2021 · Of the three classes of hydrogenases, the [FeFe] hydrogenases show the highest activity and reversibility, and, thus, have garnered special interest. In this review, we tell the story of how structural, spectroscopic, functional and theoretical studies have all contributed substantially to our modern understanding of the catalytic cycle.

The reduction of protons to form molecular hydrogen (H 2) is catalyzed by [FeFe]-hydrogenases (1, 2). With a turnover rate of up to 10,000 H 2 molecules per second in a thermodynamically reversible reaction (3 – 5), [FeFe]-hydrogenases inspired synthetic hydrogen catalysts (6 – 8) and renewable fuel technology applications (9, 10).

May 13, 2009 · Covalent Functionalization of CdSe Quantum Dot Films with Molecular [FeFe] Hydrogenase Mimics for Light-Driven Hydrogen Evolution. ACS Applied Materials & Interfaces …

Sep 13, 2007 · Terminal Hydride Species in [FeFe]-Hydrogenases Are Vibrationally Coupled to the Active Site Environment. Angewandte Chemie International Edition 2018, 57 (33) , 10605-10609.

Apr 23, 2018 · [FeFe]-Hydrogenases are the most efficient enzymes for catalytic hydrogen turnover. Their H 2 production efficiency is hitherto unrivalled. However, functional details of the catalytic machinery and possible modes of application are discussed controversially.

Dec 11, 2020 · In this light, we will herein present an overview on developments in [FeFe]-hydrogenase research with a strong focus on synthetic mimics and their application within the native enzymatic environment.