Retromer is a heteropentameric complex, which in humans is composed of a less defined membrane-associated sorting nexin dimer (SNX1, SNX2, SNX5, SNX6), and a vacuolar …

Jul 24, 2017 · Retromer is a protein coat that mediates endosomal protein sorting and trafficking. It assembles on endosomes and forms tubular vesicles that return specific transmembrane …

The retromer complex is a vital element of the endosomal protein sorting machinery that is conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

At Retromer Therapeutics, we are taking a translational approach, grounded in human genetics, to restore endolysosomal function and thereby, neuronal health. The endolysosomal system …

Nov 1, 2015 · Retrograde transport from the endosome to the Golgi is mediated by a 5 protein complex known as the retromer. These five proteins (Vps5, Vps17, Vps26, Vps29, and Vps35 …

Jan 29, 2021 · Recent biochemical and structural studies have revealed new mechanisms that govern how retromer and associated proteins sort membrane proteins at endosomes.

Feb 11, 2015 · Retromer is a protein assembly that has a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders.

Retromer is an evolutionarily conserved multimeric protein complex that mediates intracellular transport of various vesicular cargoes and functions in a wide variety of cellular processes …

Apr 5, 2025 · The retromer assists this process by stimulating the lysosomal function and mitochondrial fragmentation. Furthermore, using a Drosophila model with a long deletion in the …

Apr 7, 2020 · Retromer (red arrowhead, red arches) localizes on tubules at the early and late endosomes (EE and LE, respectively) to retrieve cargos for three main destinations: (1) for …