Jul 13, 2005 · Fresh and paraffin embedded tumor tissues from 215 Japanese patients were examined for RET rearrangements (RET /PTC1 and RET /PTC3) by means of reverse transcriptase-polymerase chain reaction analysis, with primers flanking the chimeric region, followed by direct-sequence analysis.

RET/PTC rearrangements more frequently found in PTC are RET/PTC1, given by the fusion with the CCDC6 (formerly H4) gene and RET/PTC3, given by the fusion with the NCOA4 (formerly ELE1) gene (Santoro et al., 1994).

Feb 18, 2021 · The most frequent RET fusions in PTC are coiled-coil domain containing 6 (CCDC6)–RET (also named RET–PTC1) and nuclear receptor co-activator 4 (NCOA4)–RET (also named RET–PTC3).

RET/PTC rearrangements are the most frequent molecular changes in papillary thyroid carcinoma (PTC). So far, 15 main RET/PTC rearrangements have been described, among which RET/PTC1 and RET/PTC3 are the most common in PTC - especially in radiation-induced tumours.

The prevalence of RET/PTC1, RET/PTC2, and RET/PTC3 has been found to vary between 0% and 20% in most series of sporadic (nonradiation-induced) PTCs analyzed by type-specific reverse transcription-polymerase chain reaction (RT-PCR) alone.

Sep 1, 2005 · Methods: Fresh and paraffin embedded tumor tissues from 215 Japanese patients were examined for RET rearrangements (RET/PTC1 and RET/PTC3) by means of reverse transcriptase-polymerase chain reaction analysis, with primers flanking the chimeric region, followed by direct-sequence analysis.

Mar 2, 2015 · The RET/PTC family of oncogenes, in particular RET/PTC1 and RET/PTC3, plays a key role in the development of some PTCs, especially pediatric PTCs and those associated with ionizing radiation exposure.

We used human NTs and thyrocytes infected with retroviral vector expressing RET/PTC1 (RPTC), or the RET/PTC1-Y451F mutant (RPTC-YF), as a model for PTC to investigate the cross talk between Ret/ptc1 and Met kinases and their role in thyroid carcinogenesis.

Jun 1, 2011 · The RET/PTC1 rearrangement, involving the H4 (D10S170) fusion partner, is one of the most frequently detected in PTCs. Approximately 90% of RET/PTC1-positive papillary thyroid tumors have lost the expression of the normal H4 (D10S170) allele.

Oct 25, 2004 · RET/PTC1 and RET/PTC3 are the markers for papillary thyroid carcinoma. Their reported prevalence varies broadly. Nonrearranged c-RET has also been detected in a variable proportion of...