Redox controls UPR to control redox - The Company of Biologists
Sep 1, 2014 · In many physiological contexts, intracellular reduction–oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death …
Redox signaling and unfolded protein response coordinate cell …
Jul 1, 2019 · This review will describe the regulation of UPR from the redox perspective in controlling the cell survival or death, emphasizing the redox modifications of UPR …
The unfolded protein response: controlling cell fate decisions …
Jan 18, 2012 · ER stress engages the unfolded protein response (UPR), an adaptive reaction that reduces unfolded protein load to maintain cell viability and function.
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate …
The unfolded protein response (UPR) is a collection of adaptive signaling pathways that evolved to resolve protein misfolding and restore an efficient protein-folding environment. Recent …
Redox regulation of lung endothelial PERK, unfolded protein …
Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH. Christian J Goossen. ... Redox Biol. …
Redox signaling loops in the unfolded protein response
Aug 1, 2012 · Schematic representation of redox-mediated UPR activation and amplification loops — UPR signaling, including oxidative protein folding, is activated when misfolded proteins …
Redox controls UPR to control redox - PubMed
Sep 1, 2014 · In many physiological contexts, intracellular reduction-oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death …
Real-Time Redox Measurements during Endoplasmic Reticulum …
Nov 28, 2008 · Disruption of protein folding in the endoplasmic reticulum (ER) causes unfolded proteins to accumulate, triggering the unfolded protein response (UPR). UPR outputs in turn …
PDI is an essential redox-sensitive activator of PERK during the ...
Aug 10, 2017 · Endoplasmic reticulum (ER) stress leads to activation of the unfolded protein response (UPR) that results in transient suppression of protein translation to allow recovery …
Redox regulation of UPR signalling and mitochondrial ER
Jun 7, 2024 · This review highlights the emerging evidence related to the role of redox mediated UPR activation in orchestrating inter-organelle communication between the ER and …