Jun 15, 2018 · rb1 is necessary for neural precursor cell cycle exit and terminal differentiation, rbbp4 is required for survival of postmitotic precursors, and hdac1 maintains proliferation of the neural stem cell/progenitor pool.

The non-coding RNA KTN1-AS1 binds to HDAC1 via RBBP4 in esophageal cancer to weaken the acetylation of histone H3 (ac-H3) at the promoter region of E-cadherin, thereby activating epithelial mesenchymal transition (EMT), an important process of tumor malignant progression (Chen et al., 2022).

Our study provides novel insights into the tumor suppressive role of zebrafish Rb1 and its candidate interacting proteins Rbbp4 and Hdac1 in driving persistent tumor growth, and identifies Rbbp4 as a potential target to inhibit tumor cell survival.

In this study, the expression of HDAC1 and RBBP4 was detected by IHC and western blot, and the correlation between HDAC1, RBBP4 and ER, PR, HER-2 was explored. We assess the relationship between them and clinicopathological factors and prognosis.

May 24, 2024 · With a luciferase-based HDACI/II-activity assay, we measured robust HDAC activity in the eluates from HDAC1, SIN3B, and RBBP4 IPs (Fig. 3a).

Mar 1, 2020 · HDAC1 and RBBP4 were negatively correlated with ER and PR in BC, respectively. The patients with high expression of RBBP4 had a worse overall survival time. The expression of RBBP4 was found to be significantly correlated with lymph node metastasis.

Sep 1, 2024 · MTA1 brings two HDAC1/2 molecules and four RBBP4/7 molecules into the NuRD complex via its ELM2-SANT domain and C-terminus, respectively [76]. A central helical domain (ELM2 dimerization domain) of MTA1 mediates the dimerization of the HDAC complex.

Jun 1, 2018 · Germline mutant analysis confirms that zebrafish rb1, rbbp4 and hdac1 are required during brain development. rb1 is necessary for neural precursor cell cycle exit and terminal differentiation,...

Apr 14, 2020 · RBBP4 is essential during early embryo development in vivo, loss of RBBP4 results in defective inner cell mass (ICM), severe DNA damage and apoptosis, hyperacetylated histones and preimplantation lethality in mice.

RBBP4 coexists with HDAC1 in deacetylase complexes that broadly deacetylatelysines (Johnson et al. 2002). One of these, the NuRD complex, where RBBP4, MTA1, and HDAC1 are core subunits, was found to bind to nearly all active enhancers and promoters in ESCs ( Hoffmann and Spengler 2019 ).