The mouse stomach pH was 3.0 (fed) and 4.0 (fasted), and the corresponding values in the rat were 3.2 (fed) and 3.9 (fasted). The mean intestinal pH was lower than that in man (<pH 5.2 in the mouse; <pH 6.6 in the rat).

The gastrointestinal pH in rats has been reported under various conditions [10,11,12,13]. For example, the pH in their stomach has been measured after administering proton pump inhibitors (PPIs) [ 13 ].

Table 1 The pH values of the mouse and rat gastrointestinal tract Gastrointestinal section Stomach Duodenum Jejunum Ileum Caecum Proximal colon

Jun 20, 2003 · Normal variations may occur within the rat population based on strain type, age, sex or if the animal has fasted. Values from blood or tissue samples may vary slightly, based on the Lab the specimens are sent to and its equipment calibrations.

The aim of this study was to describe gastric pH in rats at fasted state and to evaluate its changes induced by pentagastrin or omeprazole in order to mimic gastric pH at fasted and fed human subjects.

"The pH of the contents of the different gastrointestinal sections of fed and fasted mice and rats are shown in Figures 1 and 2, and in Table 1."

Jan 1, 2008 · The mouse stomach pH was 3.0 (fed) and 4.0 (fasted), and the corresponding values in the rat were 3.2 (fed) and 3.9 (fasted). The mean intestinal pH was lower than that in man (<pH 5.2 in...

The low pH values for the mouse and rat gastrointestinal tract shown in this paper (pH < 7.0) suggest that rats and mice may not be the most appropriate models for the study of pH sensitive dosage forms targeted to the human lower intestine and colon, where pH is often greater than 7.0.

Higher intestinal pH values up to pH 7.4 have been observed in older rats (>38 weeks), however, indicating that they may be more useful for modeling GI pH in place of typically used younger...

"Overall, the mean intestinal pH of both mice and rats does not reach the pH values reported in man i.e. 7.5, 6.4 and 7 in the distal small intestine, caecum and colon, respectively (primary source)."