Lipopolysaccharide enters the rat brain by a lipoprotein-mediated ...
Oct 13, 2017 · Our results suggest that LPS infiltrates in the brain in physiological conditions, possibly, through a lipoprotein transport mechanism, and it is bound to its receptors in blood …
Exploring LPS-induced sepsis in rats and mice as a model to study ...
We evaluated the suitability of an experimental lipopolysaccharide (LPS)-induced sepsis model for studying changes in the nociceptin system. C57BL/6 mice BALB/c mice and Wistar rats were …
"Lipopolysaccharide-induced animal models for …
Feb 15, 2024 · When TLR4 binds to LPS, it triggers a signaling cascade that activates various immune responses, including the production of pro-inflammatory cytokines. The recognition of …
Lipopolysaccharide exposure in a rat sepsis model results in ...
The LPS-treated rats demonstrated a significant deficit in temporal object recognition when compared with control rats (p < 0.0001). In a cued-recall paradigm, the LPS-treated rats were …
Lipopolysaccharide-induced acute lung injury in rats ... - PubMed
Feb 8, 2013 · Lipopolysaccharide (LPS) is widely used as septic model of ALI in pharmacological research. This study compares intratracheal bolus instillation (IT) with dose-adjusted aerosol …
Comprehensive Evaluation of Lipopolysaccharide-Induced Changes in Rats ...
In the present study, we used GC–MS coupled with univariate and multivariate analyses to elucidate the LPS-induced changes in metabolites occurring in the serum, liver, kidney, …
Lipopolysaccharide-induced memory impairment in rats: a …
Sep 22, 2017 · Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to …
Lipopolysaccharide Exposure Differentially Alters Plasma and Brain ...
Neonatal LPS exposure produces profound alterations in microglial morphology in the PFC in middle-aged male and female rats, indicating an activated state, and an effect that was …
Refinement of LPS induced Sepsis in SD Rats to Mimic Human …
The present study aims to develop and standardize the effective concentration of Lipopolysaccharides (LPS) for induction of sepsis in male and female Sprague Dawley (SD) …
Early effects of LPS-induced neuroinflammation on the rat …
Oct 11, 2022 · We used two approaches (in vivo and ex vivo) to evaluate the effects of lipopolysaccharide (LPS)-induced neuroinflammation on neurometabolic reprogramming, and …