Ras and Rho proteins are GTP-regulated molecular switches that control multiple signaling pathways in eukaryotic cells. Ras was among the first identified oncogenes, and it appears mutated in many forms of human cancer. It mainly promotes ...

This review provides the basic characteristics and physiological effects of Rho/ROCK signal pathway, the relationships between Rho/ROCK signal pathway and diseases, and the therapeutic methods based on the Rho/ROCK signal pathway.

Sep 15, 2019 · RhoA/ROCK interacts with OA pathological factors and induces cartilage degeneration through the degradation of chondrocyte extracellular matrix (ECM). As the RhoA/ROCK activity can affect bone formation by triggering cartilage degradation, it may represent a possible therapeutic target to treat OA.

Jun 2, 2016 · ROCK又称Rho激酶 (Rho-associated kinase),是目前功能研究最为详细的Rho下游靶效应分子。 Rho/ROCK信号通路诱导细胞骨架重组、细胞迁移和应力纤维形成,与内皮通透性、组织收缩和生长等多种生理功能有关,参与糖尿病肾病、眼疾病、肿瘤、心脏病、神经损伤性疾病、高血压、辐射损伤和白血病等疾病的发生,作为药物研发靶点越来越得到人们的关注。 本文主要针对Rho/ROCK信号通路的基本生物学特征、生理学作用与疾病的相关性和作为治疗靶点的治疗方 …

Jun 12, 2016 · Rho GTPases belong to Ras superfamily, which is reported to involve in cell migration, phagocytosis, contraction and adhesion. ROCK (also known as Rho-associated kinase) is considered to be...

We show that the sustained ERK–MAP kinase signalling resulting from transformation by oncogenic Ras down‐regulates ROCK1 and Rho‐kinase, two Rho effectors required for actin stress fibre formation.

May 5, 2023 · Rho/Rho-associated coiled-coil containing protein kinase (ROCK) receptors are exclusively expressed in the brain and Rho/ROCK signaling has gained considerable attention as it plays a crucial role in the development of neuronal architecture and structural plasticity.

Jan 22, 2009 · The Rho-ROCK pathway is implicated in Ras-mediated transformation, the amoeboid movement of tumor cells in the three-dimensional matrix, and transmigration of tumor cells through the mesothelial monolayer. On the other hand, the Rho-mDia1 pathway is implicated in Src-mediated remodeling of focal adhesions and migration of tumor cells.

Oct 12, 2009 · Stimulation of EGFR signaling in articular chondrocytes by TGF α resulted in the activation of RhoA/ROCK (Rho kinase), MEK (MAPK/ERK kinase)/ERK (extracellular-signal-regulated kinase), PI3K...

摘要: Ras同源基因家族蛋白A (RhoA)是一种小的鸟苷三磷酸酶蛋白,在缺血性卒中发生发展过程中可激活Rho相关卷曲螺旋蛋白激酶 (ROCK)｡RhoA/ROCK信号通路是缺血性卒中病理过程中的重要调节因子,调控该信号通路已成为促进缺血性卒中后神经细胞恢复和改善脑缺血-再灌注损伤的研究热点,然而目前RhoA/ROCK抑制剂仅有法舒地尔上市,其余仍处于研发或临床试验阶段｡作者对RhoA/ROCK信号通路对缺血性卒中发挥的调控作用及机制进行总结,并对抑制剂及调控药物的 …