Jul 13, 2017 · Here, we discuss RAS-mediated posttranslational modifications (PTMs) of c-MYC (MYC) that increase MYC activity and position MYC as a critical effector of RAS-driven cancer.

RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS being the most frequently mutated and MYC the most amplified. The cooperative interplay between RAS and MYC constitutes a complex and multifaceted …

Jan 2, 2025 · We report a homeostatic function of the inflammasome in suppressing malignant transformation through Ras inhibition. We identified increased hematopoietic stem cell (HSC) proliferation within the...

Nov 30, 2017 · In a mouse lung model of KRas G12D -driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma.

Sep 15, 2020 · Myc and Ras are two of the most commonly activated oncogenes in tumorigenesis. Together and independently they regulate many cancer hallmarks including proliferation, apoptosis, and self-renewal.

Sep 15, 2020 · Myc and Ras are biologically distinguishable and yet interdependent and cooperate both physiologically in normal cells and tissues and pathologically during tumorigenesis. Myc is a family of transcription factors, c-, l-, and n-Myc, whereas Ras is a family of GTPases, H-, K-, and N-Ras.

The key to oncogenic KRAS and MYC working together is the stabilization of MYC expression due to KRAS activating the extracellular signal–regulated kinase 1/2, which phosphorylates MYC at serine 62 (Ser 62). This prevents the proteasomal degradation of MYC while enhancing its transcriptional activity.

Oct 19, 2020 · Using lineage tracing and molecular profiling, Abate-Shen and colleagues identify a Ras and Myc co-activation signature that predicts metastasis and castration resistance in localized prostate...

Aug 21, 2024 · RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS being the most frequently mutated and MYC the most amplified. The cooperative interplay between RAS and...

We show here that activation of RAS alone induced senescence while activation of MYC alone or together with RAS triggered DNA damage, induction of p53 and massive apoptosis, suggesting that RAS cannot rescue MYC-induced apoptosis in this system.