Sep 30, 2021 · Here we review the role of the renin-angiotensin system (RAS) in CNS tumors and degenerative diseases, to highlight common molecular features and examine the potential merits in repurposing drugs that inhibit the RAS, its bypass loops, and converging signaling pathways.

Recently, a new ATII-progenitor cell population called RAS cells was discovered for the first time . The RAS cells population is described as a distal lung progenitor niche that rapidly differentiates into ATII cells under the strict control of Notch and Wnt signaling pathways .

Jun 24, 2021 · Angiotensin II (ATII), the physiologically active end-product of the paracrine RAS, activates ATII receptor 1 (AT 1 R) leading to increased tumor cell proliferation, oxidative stress, hypoxia and angiogenesis, and inflammation — the hallmarks of cancer. This contributes to an inflammatory TME by increasing the number of inflammatory cells ...

Jul 1, 2003 · Although the renin angiotensin system (RAS) is a major regulator of vascular homeostasis, the role of the RAS in tumor angiogenesis is little understood. Here we show that host angiotensin II (ATII) type 1 (AT1) receptor plays an important role in angiogenesis and growth of tumor cells engrafted in mice.

Mar 18, 2021 · ATII cells with both RAS- and TGF-β signaling induced, leads to an EMT proteomic signature, which is mainly driven by RAS signaling. These findings are key to further understanding the mechanisms underlying lung disease.

Jul 26, 2018 · Here we provide evidence that ZEB1-mediated EMT in human alveolar epithelial type II (ATII) cells contributes to the development of lung fibrosis by paracrine signalling to underlying...

The renin-angiotensin system (RAS), classically known for its role in cardiovascular homeostasis, is increasingly recognized to be dysregulated in cancer. Epidemiological studies have largely demonstrated a cancer-protective role of RAS inhibitors (RASi), which is...

Instead, recent findings suggest that alveolar epithelial type II (ATII) cells undergoing EMT promote a pro-fibrotic microenvironment through paracrine signalling activating local fibroblasts. This review paper explores the contribution of ATII cells, which have undergone EMT, in the context of pulmonary fibrosis.

Mar 15, 2023 · The major effector peptide of RAS, angiotensin II (ATII), stimulates hematopoietic progenitor cell proliferation via binding to angiotensin type 1a (AT1a) receptors present on CD34 + hematopoietic stem cells.

Here we review the role of the renin-angiotensin system (RAS) in CNS tumors and degenerative diseases, to highlight common molecular features and examine the potential merits in repurposing drugs that inhibit the RAS, its bypass loops, and converging signaling pathways.