Jun 1, 2020 · Oncogenic Ras assembles and activates its effectors at the membrane, initiating signaling pathways that lead to cell growth and proliferation [1••, 2•, 3•]. The two major …

In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated in many cancers, multiple K-Ras proteins are thought to assemble at the cell membrane with Ras …

H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding proteins. Recent work has shown that Ras proteins are laterally segregated into non-overlapping, …

Jan 27, 2025 · Our findings delineate ARAF–RAS protein condensates as distinct subcellular structures sustaining RAS activity and facilitating oncogenic RAS signaling. Targeting …

Mar 8, 2019 · In this study, we designed a single-molecule assay to resolve the time between initial receptor-mediated membrane recruitment and the initiation of GEF activity of individual …

Apr 4, 2023 · The structure and composition of membrane-bound RAS complexes is dynamic, but defined states appear to exist. We previously found biological and biophysical evidence for two …

May 13, 2021 · Our findings reveal membraneless, higher-order cytoplasmic protein assembly as a distinct subcellular platform for organizing oncogenic RTK and RAS signaling.

In this review, we will discuss the spatiotemporal organization of Ras proteins on the cell plasma membrane (PM) and the emergent signaling consequences of the attendant spatial distribution …

Feb 2, 2024 · Here, size-tunable nanodisc platforms and paramagnetic relaxation enhancement (PRE) analyses revealed the structural basis of cooperative assembly processes of fully …

Jun 1, 2000 · In addition to being regulated by Ras, Rho‐GTPases establish a network of stimulatory/inhibitory functional interactions among themselves. We will focus on the current …