RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin …

RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The …

RANKL regulates osteolytic bone metastasis through the stimulation of cancer cell migration toward the bone. RANKL acts directly on RANK-expressing tumor cells and promotes cell …

RANKL is a transmembrane molecule expressed by mesenchymal cell and lymphocytes. The soluble form of RANKL is a consequence of proteolytic cleavage. RANKL binds to RANK on …

RANKL/RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and remodeling and in a variety of pathologic conditions characterized by increased …

Nov 27, 2018 · RANKL signaling drives osteoclastogenesis. In BMSCs, RANKL binding to RANK activates RANKL forward signaling, which inhibits osteoblast differentiation.

Sep 10, 2024 · RANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that …

Feb 7, 2020 · RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. …

Feb 7, 2020 · RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. …

Oct 20, 2014 · RANKL–RANK–OPG are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies, and share signaling characteristics common to many members of each.