The molecular components and signaling events in the many distinct NF-κB activation pathways induced following ligation of separate receptor families (e.g., TNFR, IL-1R, RANK, TCR, BCR, …

Unexpectedly, it plays a prominent role in RANK-induced classical NF-κB activation in mammary epithelial cells (Cao et al. 2001), through NF-κB-mediated optimal cyclin D1 induction. It is, …

Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to …

In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are …

Oct 30, 2006 · IKKα may function as part of the classical IKK complex to confer RANK ligand-induced NF-κB activation, which in turn activates cyclin D1 expression and proliferation of …

Jul 15, 2008 · A number of groups have reported that NF-κB-dependent gene expression in response to some classical pathway stimuli occurs in IKKβ-deficient murine embryonic …

In unstimulated cells, the NF-kB proteins are predo-minantly localized in the cytoplasm and are associated with a family of inhibitory proteins known as IkB, which include IkBa, IkBb, IkBe …

Nov 22, 1999 · Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

One of the key steps in activating the NF-κB pathway is the stimulation of the IκB (inhibitor of κB) kinases. Recent data indicate that these kinases activate the NF-κB pathway through distinct …

IkBg corresponds to the C-terminal domain of p105 and is encoded by an mRNA initiated from an internal nfkb1 promoter.