RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene. [5][6] The protein encoded by this gene shares similarity with …

Oct 26, 2018 · Rad52 is among the most important proteins for genome maintenance in yeast, but it seemed mysteriously inconsequential for DNA repair in higher eukaryotes. However, this …

At DNA double-strand breaks, RAD52 was demonstrated to spur alternative pathways to compensate for the loss of homologous recombination functions. At collapsed replication forks, …

RAD52 is a key mediator of the HR-based DNA repair mechanism in yeast. RAD52 has a key role in recruiting RAD51 on Double Strand Break (DSB) sites and in promoting the annealing of …

Apr 24, 2024 · RAD52 is important for the repair of DNA double-stranded breaks 1, 2, mitotic DNA synthesis 3, 4, 5 and alternative telomere length maintenance 6, 7. Central to these functions, …

RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination. Oncogene. 2013;32 …

Mar 30, 2025 · RAD52 (RAD52 Homolog, DNA Repair Protein) is a Protein Coding gene. Diseases associated with RAD52 include Werner Syndrome and Short-Rib Thoracic Dysplasia …

Aug 25, 2009 · What is the Rad52 protein? The Saccharomyces cerevisiae Rad52 protein is a key player in DNA double-strand break repair and homologous recombination. It forms a …

Nov 23, 2021 · Rad52 is one of the key HR proteins in eukaryotes. Although it is critical for most DNA repair and recombination events in yeast, knockouts of mammalian RAD52 lack any …

Feb 10, 2020 · In this review, we describe recent advances on RAD52’s key functions at stalled or collapsed DNA replication forks, in particular, the unexpected role of RAD52 as a gatekeeper, …