Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules. [1] . Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry.

Racemase (α-methylacyl-coenzyme A [CoA] racemase [AMACR] or P504S) is invaluable for separating benign and neoplastic acini, including evaluation of PIN, ASAP, and separation of cancer from hormonally treated benign acini. This well-characterized enzyme catalyzes the conversion of several (2R)-methyl-branched-chain fatty acyl-CoAs to (S ...

Nov 27, 2024 · Racemases are enzymes that convert molecules from one stereoisomer to another, specifically interconverting enantiomers. This process is important for various biological functions and metabolic pathways. Understanding racemases’ mechanisms and roles can provide insights into their potential applications in biotechnology and medicine.

An enzyme capable of catalyzing racemization, that is, inversions of asymmetric groups; when more than one center of asymmetry is present, "epimerase" is used (for example, hydroxyproline, methylmalonyl-CoA). Farlex Partner Medical Dictionary © Farlex 2012.

Jan 1, 2003 · Therefore, amino acid racemases play a central role in d -amino acid metabolism. Most amino acid racemases require pyridoxal 5′-phosphate (PLP) as a coenzyme, but several others require no coenzymes. Recently, the structures and functions of these two classes of amino acid racemases were clarified on a molecular basis.

Racemases and epimerases catalyse changes in the stereochemical configurations of chiral centres and are of interest as model enzymes and as biotechnological tools. They also occupy pivotal positions within metabolic pathways and, hence, many of them are important drug targets.

In enzymology, an alanine racemase (EC 5.1.1.1) is an enzyme that catalyzes the chemical reaction. Hence, this enzyme has one substrate, L-alanine, and one product, D-alanine. This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives.

Serine racemase (SR, EC 5.1.1.18) is the first racemase enzyme in human biology to be identified. This enzyme converts L-serine to its enantiomer form, D-serine. D-serine acts as a neuronal signaling molecule by activating NMDA receptors in the brain.

A racemase is an enzyme that catalyzes the conversion between different forms of amino acids, such as l- and d-Asp, by using a two-base mechanism. It plays a crucial role in various biological processes, including neurotransmission and antibiotic production.

Apr 12, 2025 · The meaning of RACEMASE is any of various enzymes that catalyze racemizations and occur especially in bacteria. How to use racemase in a sentence.