In this study, using immortalized chicken DT40 B cell lines to investigate the role of the Vav/Rac signalling cascade on B cell proliferation, it is shown that the proliferative response triggered by B cell receptor activation is dramatically reduced in the absence of Vav3 expression.

In this review, we focus on a lesser-studied Ras effector pathway that leads to activation of the Rac small GTPase. Among the multitude of Rac effectors, there is increasing evidence that the p21-activated serine/threonine kinases (PAKs) may contribute significantly to cancer growth (5, 6).

Glutathione S-transferase (GST) or green fluorescent protein (GFP)-labeled PAK (p21 activated kinase)-RBD (Rac-binding domain) is an effective probe for detecting active Rac1.

Sep 2, 2024 · RAS-associated C3 botulinum toxin substrate 1 (RAC1) drives gasdermin D (GSDMD)-mediated pyroptosis in ovarian cancer (OC) through the P21-activated kinase 4 …

We find that modulation of Akt1 activity has a profound effect on modulation of 14-3-3β-Rac1-p21 activated kinase (Pak) signaling, in turn, regulating lamellipodia formation, adhesion to fibronectin and fibronectin assembly.

The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family, was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a wide range of processes associated with cell motility, survival, metabolism, ...

Nischarin regulates Rac1-dependent cell motility by interaction with and inhibition of the p21-activated kinase (PAK1). In addition to regulating the activation of PAK1, Rac1 controls multiple downstream pathways to regulate cell growth and differentiation, as well as cell motility.

Dec 15, 2002 · Evidence has been provided that direct binding of Cdc42-guanosine triphosphate (GTP) and Rac1-GTP to the N-terminal regulatory domain of the p21-activated kinase (PAK) stimulates PAK activation and actin reorganization.

Small GTPases of the Ras superfamily are capable of activating E2F-dependent transcription leading to cell proliferation, but the molecular mech-anisms are poorly understood. In this study, using immortalized chicken DT40 B cell lines to investigate the role of …

Mar 30, 2025 · Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed: 9121475).