Mar 3, 2006 · This review focuses on the role of the Rac1 and Rac2 GTPases in the activation of the various NOX family members. The role for reactive oxygen species (ROS) in cellular (patho)physiology, in particular in signal transduction, is increasingly recognized.

Rac1 has been implicated in the generation of reactive oxygen species (ROS) in several cell types, but the enzymatic origin of the ROS has not been proven. The present studies demonstrate that Nox1, a homolog of the phagocyte NADPH-oxidase …

Noxa1 can support Nox1 without Noxo1, when targeted to the plasma membrane by fusing membrane-binding sequences from Rac1 (amino acids 183 to 192) to the C terminus of Noxa1. However, membrane targeting of Noxa1 is not sufficient for activation of Nox1.

Apr 13, 2021 · Here, we found that dihydroceramide is a critical determinant of Rac1 compartmentalization and that loss of ifc causes neuronal (photoreceptor) defects by stimulating Rac1-NOX activation and cytoplasmic ROS accumulation.

May 18, 2022 · NOX is a multisubunit protein complex that generates superoxide anions or H 2 O 2 by transferring electrons from cytosolic NADPH to molecular oxygen.

Feb 20, 2018 · How Rac1-mediated signaling ends up promoting actin-related events, NOX-derived ROS, or both is poorly understood. Rac1 regulators, including scaffold proteins, are known to exert tight control over its functions.

Mar 3, 2006 · The family of NADPH oxidases (NOXes) plays an important role in the production of ROS in response to receptor agonists such as growth factors or inflammatory cytokines that signal through the Rho-like small GTPases Rac1 or Rac2.

Apr 4, 2018 · The small GTPase Rac1 is essential for the correct assembly of nicotinamide adenine dinucleotide phosphate oxidase (Nox) subunits.7 Several pathways converge in the activation of Rac1, and some evidence suggests a role in different cellular mechanisms, such as cell adhesion, chemotaxis, and vascular permeability.7 In addition to its role in ROS ...

Jan 22, 2010 · We examine whether alveolar cells can control release of O 2 − through regulated NADPH oxidase (NOX) 2 (NOX2) activity to maintain lung fluid homeostasis.

Several Nox family NADPH oxidases function as multicomponent enzyme systems. We explored determinants of assembly of the multicomponent oxidases Nox1 and Nox3 and examined the involvement of Rac1 in their regulation.