Jan 1, 2000 · Here, we demonstrate that β1 integrin ligation on human NK cells results in the activation of the p38 MAPK signaling pathway, which is required for integrin-triggered IL-8 production.

Using pharmacological inhibitors of Rac1-Nox2 enzyme complex, we reported the involvement of this holoenzyme and associated oxidative stress in the activation of p38MAPK. These findings suggest the role of Rac1-Nox2-derived oxidative stress in the activation of apoptotic MAPK pathways in the β-cell under glucolipotoxic conditions .

Jan 22, 2009 · Importantly, integrin-dependent MAPK activation, MAPK-dependent MLC phosphorylation, and clot retraction are inhibited by a Rac1 inhibitor and in Rac1 knockout platelets, indicating that integrin-induced activation of MAPK and MLC and subsequent clot retraction is Rac1-dependent.

The MAP kinase (MAPK) p38 plays a key role in regulating inflammatory responses. Here, we demonstrate that beta1 integrin ligation on human NK cells results in the activation of the p38 MAPK signaling pathway, which is required for integrin-triggered IL-8 production.

Jan 22, 2009 · Thus our study reveals dual activation mechanisms of MAPK that play distinct roles in platelet function, and also reveals a Rac1-MAPK–dependent integrin outside-in signaling pathway that stimulates cell retraction.

Jul 1, 2003 · The ERK-MAPK pathway controls Fra-1 expression transcriptionally and posttranscriptionally in colon carcinoma cells containing KRAS oncogenes (E.V. and C.J.M., unpublished results). An important role for Fra-1 in Ras-induced tumorigenesis is suggested by the fact that antisense-mediated inhibition of Fra-1 antagonizes the Ras-induced colony ...

Nov 22, 2021 · In the present study, we found that the recovery of NIS expression induced through MAPK pathway inhibition can be enhanced by potentiating RAC1 activity in thyroid cell systems.

Nov 22, 2021 · We found that the activity of another protein, the small GTPase RAC1, has an important role in this process, determining the outcome of MAPK inhibitors. Thus, our findings open new opportunities to find effective therapeutic alternatives for DTC resistant to RAI.

Dec 22, 2024 · We find that Rac1-driven melanomas manifest pleiotropic resistance mechanisms including (i) reduced dependence on BRAF/MEK, (ii) activation of alternative MAPK pathways utilizing Jun kinase and p38 MAP kinase, and (iii) a partial reliance on YAP/TAZ signaling.

Mar 29, 2024 · Our data indicated that FDPS could regulate the proliferation of ovarian GCs by modulating MAPK/ERK (mitogen-activated protein kinase/extracellular regulated protein kinases) pathway via activating Rac1 activity.