Mar 3, 2024 · A prognostic nomogram for liver hepatocellular carcinoma (LIHC) patients was developed based on RAC1-guanosine triphosphate (GTP) gene expression levels, which were validated using immunohistochemistry (IHC).

Sep 12, 2024 · RAC1 expression levels were significantly elevated in LIHC tissues compared to normal tissues. High RAC1 expression was strongly associated with advanced pathological stages and was identified as an independent factor negatively affecting overall survival.

Its binding frequency with endogenous Rac1-GTP can be facilitated by rapid immunohistochemistry (R-IHC), so that Rac1 activation in cancer formalin-fixed paraffin-embedded (FFPE) tissues can be detected . Rac1 activity can also be manipulated artificially.

May 18, 2023 · Tissue samples from seven patients with brain metastases from lung adenocarcinoma were collected for IHC staining to examine the expression changes of RAC1 (AF4200, Affinity). Cell lines and ...

Impaired Rac1 activation mediated by ITSN-1s reorganizes the cytoskeleton (increased thick actin bundles and focal adhesion (FA) complexes as well as collapse of the vimentin filament network) in favor of decreased LC cell migration and metastasis.

Jun 23, 2018 · The cut-off value of IHC for Rac1 expression was based on the percentage of Rac1 positive cells. Rac1 positive expression rate was ranged from 36% to 86.78% in studies using IHC, and a positive expression rate of 42.59% was reported in the literature using WB detection method.

Sep 12, 2024 · High RAC1 expression was strongly associated with advanced pathological stages and was identified as an independent factor negatively affecting overall survival. At both cellular and animal levels, RAC1 knockdown significantly inhibited the …

Dec 12, 2016 · To assess whether Rac1 overexpression observed in the breast cancer cell lines translates to clinical samples, we assessed Rac1 expression by immunohistochemistry (IHC) in a TMA, which consists of 33 cases of human normal breast/benign tumor tissues (NT) and 36 cases of human malignant breast tumor tissues.

A prognostic nomogram for liver hepatocellular carcinoma (LIHC) patients was developed based on RAC1-guanosine triphosphate (GTP) gene expression levels, which were validated using immunohistochemistry (IHC).

Mar 14, 2025 · In this study, immunohistochemical staining was used to detect RAC1 expression in 150 tongue cancer specimens. The correlation between RAC1 and clinical-pathological characteristics is...