Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene. [5][6][7] The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids.

Jan 1, 2018 · This review presents a synopsis of recent developments on Rab8 function. As detailed in the following sections, Rab8 regulates transport from the trans-Golgi network to the basolateral plasma membrane of epithelia, neuronal dendrites, and the ciliary membrane. Rab8 is required in cellular polarization, cellular signaling and development.

Small GTP-binding proteins of the rab family have been implicated as regulators of membrane traffic along the biosynthetic and endocytic pathways in eukaryotic cells. We have investigated the localization and function of rab8, closely related to the yeast YPT1/SEC4 gene products.

Nov 26, 2024 · The Rab11-Rab8 cascade mediated by the Rab8 guanine nucleotide exchange factor (GEF), Rabin8, orchestrates multiple membrane transport processes, but Rab membrane loading and exchange dynamics are unclear. Here, we use advanced fluorescence imaging approaches to characterize Rab11, Rab8, and Rabin8 protein dynamics.

Feb 5, 2024 · Here, we show that deregulated RAB-8 activity resulted in impaired apical UcPS, which increased sensitivity to infection and environmental stress. We also identified the SNARE VTI-1/Vti1a/b as a new RAB-8-interacting factor involved in the apical UcPS.

Jun 27, 2007 · Here we show that Rab8 is responsible for the localization of apical proteins in intestinal epithelial cells. We found that apical peptidases and transporters localized to lysosomes in the small...

Jul 15, 2014 · We discover that the small GTPase Rab8a is enriched in these ruffles and recruits phosphatidylinositol 3-kinase (PI3Kγ) as an effector by interacting directly through its Ras-binding domain....

Feb 8, 2024 · Here we investigate the RAB11-RAB8 cascade important in primary cilium assembly and neurite outgrowth, and the associated RAB8 GEF Rabin8. We developed cell lines permitting protein ablation of these essential ciliogenesis regulators enabling monitoring of cascade trafficking dynamics.

RAB8 is a small GTPase that has been implicated in various processes, including protein trafficking. Two separate studies in Nature and Cell now link RAB8 to two different human diseases —...

Rab GTPases, which form the largest branch of the Ras GTPase superfamily, regulate almost every step of vesicle-mediated trafficking. Among them, Rab8 is an essential participant in primary cilium formation.