Prevention of Rab7 oxidation by replacement of the redox-sensing thiols modulates its GTPase activity. Immunofluorescence studies revealed Rab7 expression to be enriched in central …

Jan 1, 2022 · WT Rab7 reduced αSyn-induced ROS production, mitochondrial impairment and DNA damage, confirming the functional relevance of reducing αSyn pathology. We induced …

ROS elevation may still occur in rab7 −/− T cells because autophagosome accumulation eventually inhibits autophagosome formation. Alternatively, fatty acids might still be accessible …

Feb 2, 2024 · The main findings of our study are that (a) PAECs from patients with PAH had reduced RAB7 expression and impaired endosome-lysosome function; (b) endothelial …

The data suggest that redox-dependent changes in Rab7 activity modulate inflammatory pain sensitivity. Rab7 is a newly identified redox target in the nociceptive system. Mice deficient for …

ROS signaling in the nociceptive system remain largely elusive. Here, we performed a proteome screen for pain-dependent redox regulation using an OxICAT approach, thereby identifying the …

May 5, 2017 · Rab7 GTPase siRNA knocking down in isolated bone marrow lal −/− MDSCs or HD1B cells not only reduced over-activation of mTOR and its downstream effector S6, but also …

Knockout mice lacking Rab7 in sensory neurons showed normal responses to noxious thermal and mechanical stimuli; however, their pain behavior during inflammatory pain and in response …

Apr 1, 2017 · Knockout mice lacking Rab7 in sensory neurons showed normal responses to noxious thermal and mechanical stimuli, however their pain behavior during inflammatory pain …

Rab5 is localised to the EE and aids its fusion and formation. Rab6 is involved with regulating intra-Golgi trafficking. Rab7 is localised to the late endosome (LE), lysosome (L), and …