A trimeric Rab7 GEF controls NPC1-dependent lysosomal ... - Nature
Nov 3, 2020 · Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL …
Structure of the metazoan Rab7 GEF complex Mon1–Ccz1–Bulli
In metazoans, Rab7 controls endosomal maturation, autophagy, and lysosomal function. It is activated by the guanine nucleotide exchange factor (GEF) complex Mon1–Ccz1–Bulli …
This Is the End: Regulation of Rab7 Nucleotide Binding in …
This review will discuss the GEF and GAPs that control Rab7 nucleotide binding, and thus regulate Rab7’s activity in endolysosomal trafficking and autophagy. It will also consider how …
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol ...
Nov 3, 2020 · The trimeric Mon1-Ccz1-C18orf8 (MCC) GEF therefore plays a central role in cellular cholesterol homeostasis coordinating Rab7 activation, endosomal LDL trafficking and …
Regulatory sites in the Mon1–Ccz1 complex control Rab5 to Rab7 ... - PNAS
One hallmark of endosomal maturation is the transition from the early endosomal Rab5 to the late endosomal Rab7. Rab GTPases serve as identity markers for organelles. One key regulator of …
Rab GTPase Function in Endosome and Lysosome Biogenesis
Jul 16, 2018 · Rab GTPases are key factors that determine organelle identity throughout the endomembrane system. Endosomes change identity by replacing Rab5 with Rab7, which …
Rab GEFs and GAPs - PMC - PubMed Central (PMC)
Rab7 has long been known to be a central regulator of lysosomes and diverse lysosome-like organelles. However, it still remains unclear how it is regulated in all these cases. Early studies …
A trimeric metazoan Rab7 GEF complex is crucial for ... - PubMed
Jul 9, 2020 · Recruitment of Rab7 to endosomes requires the Mon1-Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the Drosophila Mon1-Ccz1 complex …
Rab7: Role of its protein interaction cascades in endo-lysosomal ...
Mar 1, 2011 · Like other Rab proteins, Rab7 is activated by a set of upstream regulators that converge on its GEF (guanine-nucleotide exchange factor) and GAP (GTPase activation …
The Mon1–Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin …
Mar 1, 2014 · We previously identified the conserved Mon1–Ccz1 complex as the guanine nucleotide exchange factor (GEF) of the yeast Rab7 GTPase Ypt7. To address the possible …