RAB7A functions as a key regulator in endo-lysosomal trafficking, governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal …

Consistently, mutations or dysfunctions of Rab7 result in traffic disorders, which cause various diseases, such as neuropathy, cancer and lipid metabolism disease. Rab7 also plays …

In this review article, we have summarized recent findings regarding the functions of Rab7 in mammalian autophagy, especially focusing on Rab7 KO in cultured cells and in mice.

Recent evidence suggests that Rab7 function can be modulated by the combination of several post-translational modifications that facilitate interactions with one effector while preventing …

RAB7 (Ras-related in brain 7) oncogenic functions in cancer progression. RAB7A determines the acquisition of invasion and metastasis features through different routes: (i) inducing actin …

In this review, we discussed the main functions of the small GTPase Rab7 highlighting that the central role of Rab7 for correct cargo selection, biogenesis, positioning, motility and …

Nov 19, 2018 · Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in …

May 1, 2022 · To determine the role of RAB7 in the endocytic pathway, we used siRNA to deplete endogenous RAB7 and examine cargo trafficking and compartment biogenesis. Using this …

'Rab7 Protein is a type of Rab protein that plays a crucial role in regulating endo-lysosomal membrane traffic by converting from GDP-bound to GTP-bound form. It interacts with various …

Mar 1, 2011 · Rab7, a small GTPase of the Rab family associated with both the endosome and lysosome, was investigated extensively and well recognized to facilitate endosomal …