LC3-associated endocytosis and the functions of Rubicon and …
Oct 26, 2022 · LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …
Regulation of autophagy by the Rab GTPase network - PMC
Imaging and quantification data showed that expression of dominant-negative GFP-Rab5 not only changed the distribution pattern of mCherry-LC3 but also severely weakened NS4B-induced …
Rab5 modulates mutant huntingtin aggregation/toxicity in cell …
May 5, 2008 · Inhibition of Rab5 resulted in a decrease in LC3-positive vesicles suggesting a defect in the formation of autophagic vacuoles. Rab5 is an activator of Vps34, a PI-3-kinase …
Subversion of RAB5-regulated autophagy by the intracellular …
RAB5 also regulates degradation of intracellular components by coordinating the fusion of LC3-decorated autophagosomes with late endosomes to form intermediary compartments before …
gation of LC3 to Rab5+, clathrin+ endosomes con-taining b-amyloid in a process of LC3-associated endocytosis (LANDO). We found that LANDO in mi-croglia is a critical regulator of …
RAB5c controls the assembly of non-canonical autophagy
Mar 25, 2025 · One such pathway is LC3-associated phagocytosis (LAP), which aids in phagosome maturation and subsequent signaling upon cargo uptake mediated by certain …
LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and ...
Jul 25, 2019 · We have identified a novel non-canonical function of several autophagy proteins in the conjugation of LC3 to Rab5+, clathrin + endosomes containing β-amyloid in a process of …
Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 …
Apr 11, 2013 · Here we show that, upon growth factor limitation, the p110β catalytic subunit of the class IA phosphoinositide 3-kinases (PI3Ks) dissociates from growth factor receptor …
Rab5 modulates aggregation and toxicity of mutant huntingtin …
May 15, 2008 · Our data suggest that Rab5, previously considered as a specific endosome marker, also influences mammalian autophagy. Inhibition of Rab5 resulted in a decrease in …
Restructuring of the plasma membrane upon damage by LC3
We propose that a form of macropinocytosis coupled to noncanonical autophagy, which we term LC3-associated macropinocytosis (LAM) functions to remove damaged material from the …