RAB2B follows mainly exocytic pathways, from the endoplasmic reticulum to Golgi complex. RAB proteins are involved in docking and fusion of transport vesicles with their target membranes. These proteins associate with effector proteins (GARIL4 and GARIL5) to create complexes.

Rab2B overexpression promotes increase in basal ERK activity. GRASP65 is a target of Rab2B-stimulated ERK activation. ERK phosphorylated GRASP65 prevented ERGIC-Golgi transport. GRASP65 phosphorylation promotes Golgi discontinuities that alter protein O-glycosylation.

Here, we show that RAB2 connects the Golgi network to autophagy pathway by delivering membrane and by sequentially engaging distinct autophagy machineries. In unstressed cells, RAB2 resides primarily in the Golgi apparatus, as evidenced by its interaction and colocalization with GOLGA2/GM130.

Rab2b Downregulation of Rab2b levels causes G0/G1 cell cycle arrest and promotes apoptosis in PANC-1 cells and alters the expression of cell cycle regulators, including increasing of cyclin D1 and decreasing of p21 and p27.

Mar 5, 2025 · Rab2B overexpressing NRK cells had a significant increase in steady state activated ERK. Studies were then performed to identify the Rab2-ERK1/2 substrate (s) that locate and function in the early secretory pathway. To that end, GRASP65 was identified as a target of ERK1/2 phosphorylation.

Lőrincz et al. show that Rab2 is critical for the delivery of autophagic and endocytic cargo to lysosomes and for their degradation, and that it promotes autophagosome–lysosome fusion. The results suggest Rab2 and Rab7 coordinately promote autophagic and endosomal degradation and lysosome function.

Aug 1, 2023 · We propose that increased Rab2 expression facilitates cis Golgi structural changes that are maintained and tolerated by the cell due to LC3 tagging, and subsequent membrane remodeling triggers Golgi associated signaling pathways that may contribute to oncogenesis.

They assessed the impact of Rab2B overexpression on the transport rate of Vesicular Stomatitis Virus Glycoprotein (VSV-G) in the secretory pathway. The researchers monitored the cells for the presence of the autophagic marker protein LC3, especially focusing on LC3-lipidation on Rab2-containing membranes.

Mar 30, 2025 · RAB2B (RAB2B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB2A.

Here, we show that RAB2 connects the Golgi network to autophagy pathway by delivering membrane and by sequentially engaging distinct autophagy machineries. In unstressed cells, RAB2 resides primarily in the Golgi apparatus, as evidenced by its interaction and colocalization with GOLGA2/GM130.