Rab27a and Rab27b control different steps of the exosome
Dec 6, 2009 · Using an RNA interference (RNAi) screen, we identified five Rab GTPases that promote exosome secretion in HeLa cells. Among these, Rab27a and Rab27b were found to …
RAB27A - Wikipedia
Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The …
Different NK cell–activating receptors preferentially recruit Rab27a …
Nov 5, 2009 · This study was performed by overexpression of fluorescently tagged Rab27a and Munc13-4, along with Rab7 and Rab11. Overexpression of multiple membrane fusion …
The RAB27A effector SYTL5 regulates mitophagy and …
Feb 17, 2025 · We demonstrate that SYTL5-RAB27A positive vesicles containing mitochondrial material and LAMP1 form during hypoxia and that SYTL5 and RAB27A promote mitophagy …
Rab27a and Rab27b control different steps of the exosome ... - PubMed
Using an RNA interference (RNAi) screen, we identified five Rab GTPases that promote exosome secretion in HeLa cells. Among these, Rab27a and Rab27b were found to function in MVE …
In vivo Roles of Rab27 and Its Effectors in Exocytosis - PMC
The monomeric GTPase Rab27 regulates exocytosis of a broad range of vesicles in multicellular organisms. Several effectors bind GTP-bound Rab27a and/or Rab27b on secretory vesicles to …
Rab7 and Rab27a control two motor protein activities involved in ...
Mouse coat colour mutants reveal a critical role for the small GTPase Rab27a, which recruits myosin Va through its effector protein melanophilin/Slac2a. Here we have studied how two …
RAB27A RAB27A, member RAS oncogene family [ (human)]
Rab7 controls microtubule-mediated transport of early and Rab27a the subsequent actin-dependent transport of mature melanosomes. Extensive genetic and allelic heterogeneity in …
Rab7a and Rab27b control secretion of endothelial microRNA …
Oct 7, 2015 · By screening Rab GTPases for their contribution to miR export, we found miR-143 to be dependent on Rab7a and Rab27b. Strikingly, Rab27a – the homolog of Rab27b – seems …
RAB27A - an overview | ScienceDirect Topics
RAB27, mainly RAB27A, mediates the docking, tethering and fusion of MVBs with the plasma membrane. The central role of RAB27 in exosomal secretion has been widely confirmed …