A dual role of ERGIC-localized Rabs in TMED10-mediated ... - Nature
Jun 26, 2024 · Rab1A and Rab1B (Rab1) act by promoting TMED10 oligomerization, thereby enhancing cargo translocation into the ERGIC. In contrast, Rab2A collaborates with KIF5B to …
Rab1 in Cell Signaling, Cancer and Other Diseases - PMC
Apr 20, 2022 · Rab1A and Rab1B are found predominantly at the membrane of endoplasmic reticulum (ER) and Golgi apparatus 41, 46. They have also been detected on lipid rafts 59 and …
Aurora kinase A-mediated phosphorylation triggers structural …
Activated Rab1A is retained on the ER and induces the oligomerization of ER-shaping protein RTNs and REEPs, eventually triggering an increase of ER complexity. In various models, from …
Rab1A promotes cell proliferation and migration by ... - Nature
Aug 10, 2021 · Rab1A, as a highly conserved small guanosine triphosphatase (GTPase), predominantly regulates intracellular vesicular trafficking from the endoplasmic reticulum (ER) …
Aurora kinase A-mediated phosphorylation triggers structural
Jan 4, 2024 · Activated Rab1A is retained on the ER and induces the oligomerization of ER-shaping protein RTNs and REEPs, eventually triggering an increase of ER complexity. In …
RAB1A Gene - GeneCards | RAB1A Protein | RAB1A Antibody
Mar 30, 2025 · RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth …
Rab1 GTPases as oncogenes - PMC
Rab1A overexpression specifically enhances mTORC1 signaling, tumor invasion and progression [2, 3]. Conversely, RAB1A knockdown selectively attenuates oncogenic growth and invasion of …
Dual function of Rab1A in secretion and autophagy: hypervariable …
Rab GTPases localize to specific organelles through their hypervariable domain (HVD) to regulate discrete steps of individual pathways. Here, we explored the dual role of Rab1A/B (92% …
Rab1A mediates proinsulin to insulin conversion in β-cells by ...
Aug 9, 2016 · Since a recent report showed that Rab2A is involved in the regulation of ER stress within insulin-secreting cells (Sugawara et al., 2014), we wondered whether rab1a knockout …
Rab1A Is an mTORC1 Activator and a Colorectal Oncogene
Nov 10, 2014 · Our results demonstrate that Rab1 is an mTORC1 activator and an oncogene and that hyperactive AA signaling through Rab1A overexpression drives oncogenesis and renders …