Sep 26, 2019 · We show that the membrane-organising proteins, flotillin-1 and -2, are required for TCR to reach Rab5-positive endosomes immediately after endocytosis and for transfer from Rab5- to...

Apr 9, 2018 · Here we describe that WIPI2 localizes to autophagic precursor membranes by binding RAB11A, a protein that specifies recycling endosomes, and that PI3P is formed on RAB11A-positive membranes upon starvation. Loss of RAB11A impairs the recruitment and assembly of the autophagic machinery.

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. [7]

Aug 24, 2022 · We demonstrate that increased TfR recycling is powered by a fast endocytic sorting pathway relying on the membrane proteins flotillins, Rab5- and Rab11a-positive endosomes.

Here, we identify Rab11a and Rab11b as regulators of Ca 2+ -induced lysosome exocytosis. Interestingly, Rab11-positive vesicles transiently interact with lysosomes at the cell periphery, indicating that this interaction is required for the last steps of lysosome exocytosis.

May 28, 2020 · Here, we investigated the role of the small GTPase Rab11A, a known regulator of exocytosis in eukaryotic cells. Our data revealed an essential role of Rab11A in promoting the cytoskeleton driven transport of dense granules and the …

Sep 26, 2019 · We show that the membrane-organising proteins, flotillin-1 and -2, are required for TCR to reach Rab5-positive endosomes immediately after endocytosis and for transfer from Rab5- to Rab11a-positive compartments.

Rab11a has a role in the trafficking of alphaVbeta3 integrin and maintenance of E-cadherin levels at the surface of endometrial epithelial cells; Reduced levels of Rab11a expression is linked to both advanced-stage carcinoma and poorer survival rates in the colorectal cancer.

Dec 22, 2016 · Downregulation of Rab8a or Rab11a in SCs reduced the formation of functional TNTs, decreased of vesicle transfer between the connected cells leading to SCs apoptosis and also suppressed axonal outgrowth from co-cultured dorsal root ganglion (DRG) neurons.

Feb 8, 2024 · Here we investigate the RAB11-RAB8 cascade important in primary cilium assembly and neurite outgrowth, and the associated RAB8 GEF Rabin8. We developed cell lines permitting protein ablation of these essential ciliogenesis regulators enabling monitoring of cascade trafficking dynamics.