Feb 7, 2024 · Rab11a activity is necessary for LC3 positive vesicle emergence at dendritic spines upon simultaneous mTOR inhibition and NMDA treatment. In final series of our experiments, we investigated causative link between Rab11 and local autophagy at the dendritic spines.

Downregulation of Rab8a or Rab11a in SCs reduced the formation of functional TNTs, decreased of vesicle transfer between the connected cells leading to SCs apoptosis and also suppressed axonal outgrowth from co-cultured dorsal root ganglion (DRG) neurons.

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. [7]

Dec 4, 2022 · In the trans-Golgi network (TGN) Rab11a routes vesicle trafficking between the TGN and ERC or plasma membrane. It plays a vital role in controlling tissue homeostasis during embryonic development and the postnatal period. Total knockout of Rab11a was found to be embryonic lethal in a mouse model.

Rab11 is involved in the transport of several growth factor molecules important for the development and repair of neurons. Overexpression of Rab11 has been shown to significantly enhance vesicle trafficking. On the other hand, a reduced expression of Rab11 was observed in several neurodegenerative diseases.

Sep 28, 2023 · It’s shown that neurons, rather than glial cells, were the primary cell type expressing Rab11a in the spinal dorsal horn (SDH). After intra-plantar injection of CFA, both the number of Fos/Rab11a-immunopositive neurons and the expression of Rab11a were increased.

Dec 22, 2016 · Overall, our results suggested that the gene of Rab8a or Rab11a might be involved in the formation of TNTs structures in the peripheral nerve system, while TNTs structures were likely to affect peripheral nerve regeneration through the regulation of neural cell communications.

Apr 9, 2018 · RAB11A-positive membranes are a primary direct platform for canonical autophagosome formation that enables autophagy of the transferrin receptor and damaged mitochondria.

Dec 22, 2016 · Downregulation of Rab8a or Rab11a in SCs reduced the formation of functional TNTs, decreased of vesicle transfer between the connected cells leading to SCs apoptosis and also suppressed axonal...

Jan 30, 2025 · RAB11A and RAB11B exhibit distinct and characteristic distributions in the brain and other organs, suggesting they play different roles throughout the body. In particular, our results suggest they make distinct contributions to cortical development and regulation of the synaptic vesicle cycle.