RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes. [7] . It drives the maturation of …

Feb 11, 2020 · In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development.

Nov 15, 2019 · Here we show instead that endocytosis is dispensable and post-Golgi vesicle transport is crucial for the formation of endosomes and the subsequent endolysosomal traffic regulated by yeast Rab5...

Nov 4, 2021 · GTPase Rab5 (Ras-related protein in brain 5) regulates endocytic uptake and homotypic fusion of early endosomes and regulates phosphatidylinositol 3-monophosphate production important for binding of effector proteins during …

Aug 24, 2004 · Rabankyrin-5, which is activated by the small GTPase Rab5, coordinates two disparate methods that cells use to take in solids and fluids, playing a key role in both endosome fusion and macropinocytosis.

Jul 2, 2007 · Characterization of the 29 Caenorhabditis elegans Rab GTPases reveals that depletion of RAB-5 phenocopies the defects in peripheral ER structure that result from depletion of RET-1 and YOP-1, the C. elegans homologues of Rtn4a and DP1/NogoA.

Jun 1, 2005 · Rab5 is one of the more intensely studied members of the large and diverse family of Rab GTPases 1. Functional studies indicate that it is a key regulator of early endocytosis, where it is...

Feb 11, 2020 · In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development.

May 23, 2012 · Our results demonstrate for the first time, to our knowledge, the role of Rab5 as an endosome organizer in vivo and reveal the resilience mechanisms of the endocytic system. What are the...

Mar 30, 2025 · RAB5A (RAB5A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5A include Lateral Sclerosis and Tuberculosis. Among its related pathways are Response of Mtb to phagocytosis and Infectious disease. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding.