The renin-angiotensin system (RAS), or renin-angiotensin-aldosterone system (RAAS), is a hormone system that regulates blood pressure, fluid, and electrolyte balance, and systemic vascular resistance.

Mar 12, 2023 · The renin-angiotensin-aldosterone system (RAAS) is a critical regulator of blood volume, electrolyte balance, and systemic vascular resistance. While the baroreceptor reflex responds in the short-term to decreased arterial pressure, the RAAS is responsible for acute and chronic alterations.

Sep 13, 2022 · The renin–angiotensin–aldosterone system (RAAS) is a critical regulator of blood volume and systemic vascular resistance on a long-term basis. The baroreceptor reflex, on the other hand, responds in a short-term manner to decreased blood pressure.

Aug 22, 2023 · The Renin-Angiotensin-Aldosterone System (RAAS) is a hormone system within the body that is essential for the regulation of blood pressure and fluid balance. The system is mainly comprised of the three hormones renin , angiotensin II, and aldosterone .

Feb 5, 2023 · Angiotensin I is cleaved to form angiotensin II by angiotensin converting enzyme (ACE), which is found predominantly within lung endothelium. ACE-inhibitors, as their name implies, targets the ACE enzyme and is one of the most potent anti-hypertensives (and GFR-preserving) therapies available.

The classical view of the renin-angiotensin system (RAS) is that of the circulating hormone pathway involved in salt and water homeostasis and blood pressure regulation. It is also involved in the pathogenesis of cardiac and renal disorders. This ...

Dec 19, 2024 · The renin-angiotensin-aldosterone system (RAAS) is a pivotal hormonal mechanism integral to cardiovascular and renal homeostasis. This comprehensive review delineates the intricate pathways of RAAS, highlighting its classical and newer axes and their multifaceted roles in physiological and pathological states.

The classic RAS comprises the ACE-Ang II-AT 1 R axis that promotes vasoconstriction, water intake, sodium retention and increased oxidative stress, fibrosis, cellular growth, and inflammation. The non-classical or alternative RAS is composed primarily of the ACE2-Ang- (1-7)-AT 7 R pathway that opposes many actions of the Ang II-AT 1 R axis.

Dec 1, 2024 · This paper delves into the classical axis (Renin-ACE-Ang II-AT1R axis), the protective arm (ACE2-Ang (1–7)-MasR axis), the prorenin-PRR-MAP kinases ERK1/2 axis, and the Ang IV-AT4R-IRAP cascade of RAAS, examining their functions in both physiological and pathological states.

Oct 1, 2017 · Out of the many systems, renin-angiotensin-aldosterone axis, or renin-angiotensin aldosterone system (RAAS) is a vital one, for survival [1]. This system maintains vascular tonicity by regulating extracellular fluid volume and arterial pressure [2].