RUNX1 - Wikipedia
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it is a protein that is encoded by …
Role of RUNX1 in hematological malignancies
Apr 13, 2017 · RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated …
The RUNX1/RUNX1T1 network: translating insights into …
RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid leukemia. Seminal contributions by many different research groups have revealed a complex regulatory network …
RUNX1 Gene - GeneCards | RUNX1 Protein | RUNX1 Antibody
Mar 30, 2025 · RUNX1 (RUNX Family Transcription Factor 1) is a Protein Coding gene. Diseases associated with RUNX1 include Platelet Disorder, Familial, With Associated Myeloid …
RUNX1: an emerging therapeutic target for cardiovascular disease
RUNX1 is best characterized for its indispensable role for definitive haematopoiesis and its involvement in haematological malignancies. However, more recently RUNX1 has been …
RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies
Mar 4, 2021 · RUNX1 familial platelet disorder with associated myeloid malignancies (RUNX1-FPDMM) is characterized by prolonged bleeding and/or easy bruising and an increased risk of …
A CRISPR RNA-binding protein screen reveals regulators of RUNX1 …
Mar 3, 2021 · Alternative polyadenylation (APA) of RUNX1 produces functionally antagonistic protein isoforms (RUNX1a vs RUNX1b/c) that mediate HSC self-renewal vs differentiation, an …
RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially …
Nov 2, 2023 · Three major RUNX1 isoforms (A, B and C) are recognized and share a DNA binding RUNT domain; RUNX1A lacks the transactivation domain. Two distinct promoters …
RUNX1 - an overview | ScienceDirect Topics
RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. It belongs to the Runt-related transcription factor (RUNX) family of genes …
Role of RUNX1 in hematological malignancies - PMC - PubMed Central …
Jan 8, 2022 · RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated …