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EMBO Press
https://www.embopress.org › doi › full
The mTOR/PI3K and MAPK pathways converge on …
Jun 8, 2006 · The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to …
Author: David Shahbazian, Philippe P Roux, Virginie Mieulet, Michael S Cohen, Brian Raught, Jack Taunton, Jo...
Publish Year: 2006
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Phosphorylation of Eukaryotic Translation Initiation Factor 4B …
Results: ORF45 increases phosphorylation of eIF4B through p90 RSKs. Conclusion: The ORF45/RSK axis promotes protein translation during lytic replication. Significance: This …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
eIF4B controls survival and proliferation and is regulated by proto ...
Oct 10, 2010 · Recent studies have shown that eIF4B is phosphorylated and activated by Ras-MAPK and PI3K-mTOR signaling cascades. In addition, eIF4B regulates translation of …
- Author: David Shahbazian, Armen Parsyan, Emmanuel Petroulakis, John W.B. Hershey, Nahum Sonenberg
- DOI: 10.4161/cc.9.20.13630
- Publish Year: 2010
- Publication: Cell Cycle. 2010 Oct 15; 9(20): 4106-4109.
Studies of RSK eIF4B
National Center for Biotechnology Information
eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways
Messenger RNA translation or protein synthesis, is a fundamental biological process affecting cell growth, survival and proliferation. Initiation is the rate limiting and hence the most regulated step of translation. In eukaryotes, translation initiation is facilitated by multiple protein factors co...
Author: David Shahba…
Published: 2010/10/10
Publication: Cell Cycle…
PubMed
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phos...
Author: David Shahba…
Published: 2006/06/21
Keywords: National In…
National Center for Biotechnology Information
RSK Activation of Translation Factor eIF4B Drives Abnormal Increases of Laminin γ2 and MYC Protein during Neoplastic Progression to Squamous Cell Carcinoma
Overexpression of the basement membrane protein Laminin γ2 (Lamγ2) is a feature of many epidermal and oral dysplasias and all invasive squamous cell carcinomas (SCCs). This abnormality has potential value as an immunohistochemical biomarker of premalignancy but its mechanism has remained unknown. We...
Author: Martin Degen, …
Published: 2013
Publication: PLoS On…
PubMed
Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication
Open reading frame 45 (ORF45) of Kaposi sarcoma-associated herpesvirus (KSHV) causes sustained activation of p90 ribosomal S6 kinase (RSK), which is crucial for KSHV lytic replication, but the exact functional roles remain to be determined. To characterize the biological consequence of persistent RS...
Author: Ersheng Kuang
Published: 2011/12/02
Keywords: National In…
National Center for Biotechnology Information
C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation
The transcription factor C/EBPβ plays a key role in monocytic differentiation and inflammation. Its small isoform LIP is associated with proliferation at early premonocytic developmental stages and regulated via mTOR-dependent signalling. During later stages of (pre)monocytic differentiation there i...
Author: René Huber, T…
Published: 2015
Publication: PLoS On…
PubMed
https://pubmed.ncbi.nlm.nih.gov
The mTOR/PI3K and MAPK pathways converge on eIF4B to control …
Jun 21, 2006 · The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Phosphorylation of Eukaryotic Translation Initiation Factor 4B …
Dec 2, 2011 · We found that ORF45 induced phosphorylation of eukaryotic translation initiation factor 4B (eIF4B), increased its assembly into translation initiation complex, and subsequently …
- Author: Ersheng Kuang, Bishi Fu, Qiming Liang, Jinjong Myoung, Fanxiu Zhu
- Publish Year: 2011
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
eIF4B is a convergent target and critical effector of oncogenic Pim …
Activation of eIF4B correlates with Abl-mediated cellular transformation, but the precise mechanisms are largely unknown. Here we show that eIF4B is a convergent substrate of …
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Is RSK an eIF4B ser422 kinase?
Here we identify RSK as an in vivo and in vitro eIF4B Ser422 kinase. Insulin‐stimulated eIF4B phosphorylation at Ser422 was previously demonstrated to be rapamycin‐sensitive, and the kinase responsible for Ser422 phosphorylation was identified as S6K (Raught et al, 2004; see also Figure 1A, compare lanes 9 and 10, upper panel).
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its
embopress.org
Why is eIF4B important?
Therefore, eIF4B is a key component in control of the major rate-limiting step of protein synthesis. eIF4B is involved in translation of numerous proliferative or anti-apoptotic mRNAs with highly structured 5′UTR and subsequently affect cell growth and survival [17, 18].
eIF4B is a convergent target and critical effector of oncogenic Pim and
pmc.ncbi.nlm.nih.gov
How does eIF4B phosphorylate mRNA?
Recent studies have shown that eIF4B is phosphorylated and activated by Ras-MAPK and PI3K-mTOR signaling cascades. In addition, eIF4B regulates translation of proliferative and pro-survival mRNAs. Moreover, eIF4B depletion in cancer cells attenuates proliferation, sensitizes them to genotoxic stress driven apoptosis.
Full article: eIF4B controls survival and proliferation and is
tandfonline.com
Which kinases are responsible for eIF4B phosphorylation?
However, given that eIF4B phosphorylation is sensitive to pharmacological inhibitors that fail to inhibit other AGC kinases, it is very likely that the major kinases responsible for eIF4B phosphorylation are S6K and RSK.
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its
embopress.org
What role does eIF4B play in translation initiation?
eIF4B plays a major role in the translation initiation most likely through stimulation of eIF4A helicase and ATPase activities, but potentially also through other mechanisms such as preventing initiation complex 3′–5′ movement and assisting in ribosome landing pad formation.
Full article: eIF4B controls survival and proliferation and is
tandfonline.com
How does eIF4B interact with eIF4F and eIF4A?
Later studies have shown that it functionally interacts with eIF4F and eIF4A potentiating their RNA helicase activities in vitro. 1 eIF4B is an RNA binding protein and is the least evolutionarily conserved translation initiation factor.
Full article: eIF4B controls survival and proliferation and is
tandfonline.com
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X-MOL科学知识平台
https://www.x-mol.com › paper
The mTOR/PI3K and MAPK pathways converge on eIF4B to control …
Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phosphorylates eIF4B on the same residue. The relative contribution of the RSK and S6K modules to the …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B …
We found that LAP*/LAP formation was induced via MEK/RSK-dependent cascades, whereas mTOR/S6K1 were not involved. Remarkably, LAP*/LAP expression was dependent on …
EMBO Press
https://www.embopress.org › doi › abs
The mTOR/PI3K and MAPK pathways converge on eIF4B to control …
Jun 8, 2006 · Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phosphorylates eIF4B on the same residue. The relative contribution of the RSK and S6K …
Taylor & Francis Online
https://www.tandfonline.com › doi › full
Full article: eIF4B controls survival and proliferation and …
Oct 15, 2010 · In this review we will analyze the bulk of data describing eIF4B and its role in cell survival and proliferation. Recent studies have shown that eIF4B is phosphorylated and activated by Ras-MAPK and PI3K-mTOR signaling …
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The mTOR/PI3K and MAPK pathways converge on …

Phosphorylation of Eukaryotic Translation Initiation Factor 4B …

eIF4B controls survival and proliferation and is regulated by proto ...

The mTOR/PI3K and MAPK pathways converge on eIF4B to control …

Phosphorylation of Eukaryotic Translation Initiation Factor 4B …

eIF4B is a convergent target and critical effector of oncogenic Pim …

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its

eIF4B is a convergent target and critical effector of oncogenic Pim and

Full article: eIF4B controls survival and proliferation and is

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its

Full article: eIF4B controls survival and proliferation and is

Full article: eIF4B controls survival and proliferation and is

The mTOR/PI3K and MAPK pathways converge on eIF4B to control …

C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B …

The mTOR/PI3K and MAPK pathways converge on eIF4B to control …

Full article: eIF4B controls survival and proliferation and …

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