ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major …

Mar 30, 2025 · ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) is a Protein Coding gene. Diseases associated with ROCK1 include Omphalocele and Hutchinson-Gilford …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in diverse cellular …

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or progression is not …

ROCKs (ROCK1 and ROCK2) occur in mammals (human, rat, mouse, cow), zebrafish, Xenopus, invertebrates (C. elegans, mosquito, Drosophila) and chicken. Human ROCK1 has a …

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly. ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating …

Jul 23, 2013 · These results show that ROCK1 acts as a prominent upstream regulator of Beclin1-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy. …

ROCK1 is a protein that was discovered as a downstream target of the small GTP-binding protein RhoA. It plays a significant role in mediating cell motility, proliferation, apoptosis, and the …

Feb 8, 2025 · ROCK1 in bone marrow-derived cells is a critical mediator of atherogenesis; macrophage ROCK1 may be an important therapeutic target for vascular inflammation and …

The protein serine/threonine kinase ROCK1 is a downstream effector for the small GTPase Rho (RHOA; 165390). ROCK1 is involved in a wide range of physiologic and pathologic processes …