Apr 3, 2025 · The m5C modification is a widespread RNA modification detected in mRNA and non-coding RNAs including transfer RNA, ribosomal RNA, long non-coding RNA, small non …

Liu et al. present a comprehensive view of the mRNA m5C landscapes during HSPC developmental switches and show that Ybx1 cooperates with Pabpc1a to maintain the stability …

In this review, we outline the current detection methods of m 5 C in RNA, explore their advantages and disadvantages, and review the m 5 C distribution pattern and advances in RNA m 5 C …

May 5, 2022 · Here, we generate quantitative mRNA m 5 C maps at different stages of development in 6 vertebrate and invertebrate species and find convergent and unexpected …

Apr 18, 2017 · Our study provides comprehensive m5C profiles of mammalian transcriptomes and suggests an essential role for m5C modification in mRNA export and post-transcriptional …

Apr 1, 2022 · As reversible epigenetic modifications, m5C modifications of RNA affect the fate of the modified RNA molecules and play important roles in various biological processes including …

Dec 3, 2024 · RNA m5C modification regulates metabolism, stability, nuclear export, and translation of RNA molecules. An increasing number of studies have revealed the critical roles …

Aug 8, 2024 · 5-methylcytosine (m 5 C) is a prevalent RNA modification crucial for gene expression regulation. However, accurate and sensitive m 5 C sites identification remains …

Identifying these m5C reader proteins is essential for elucidating the mechanisms that influence the fate and function of m5C-modified RNA. The currently known m5C reader proteins include …

Dec 8, 2009 · Numerous putative RNA:m 5 C-MTases have now been identified and are awaiting characterization, including the identification of their RNA substrates and their related cellular …