Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling. [5] Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. [6] .

Mar 30, 2025 · RGS4 (Regulator Of G Protein Signaling 4) is a Protein Coding gene. Diseases associated with RGS4 include Bipolar Disorder and Schizophrenia. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding.

Jun 25, 2021 · The Regulator of G protein signaling 4 (Rgs4) is a member of the RGS proteins superfamily that modulates the activity of G-protein coupled receptors.

Regulator of G protein signaling 4 (Rgs4) is a signal transduction protein that controls the function of monoamine, opiate, muscarinic, and other G protein-coupled receptors via interactions with Gα subunits.

Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of Gα-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor.

Oct 1, 2020 · To understand the principles governing the selectivity of Gα regulation by RGS, we examine the catalytic activity of all canonical human RGS proteins and their selectivity for a complete set of Gα substrates using real-time kinetic measurements in living cells.

RGS4 is a helical protein containing nine alpha helices connected by turns and loops (Tesmer et al., 1997). You might find these chapters and articles relevant to this topic. Melinda D. Willard, ... David P. Siderovski, in Handbook of Cell Signaling (Second Edition), 2010. The R4 family of RGS proteins is the largest in mammals, with 10 members.

Feb 8, 2025 · Rgs4 regulates vascular endothelial growth factor signaling. These results establish RGS4 and RGS5 as in vivo substrates of the mammalian N-end rule pathway and also suggest that the O2-ATE1-UBR1/UBR2 proteolytic circuit plays a role in RGS-regulated G protein signaling in the cardiovascular system.

RGS4 is a GTP-activating protein (GAP) that selectively terminates A 1 R signalling at the level of G protein activation, by accelerating the intrinsic GTPase self-mediated hydrolysis and thus reverting Gα and Gβγ subunits to an inactive state .

Jun 25, 2021 · The Regulator of G protein signaling 4 (Rgs4) is a member of the RGS proteins superfamily that modulates the activity of G-protein coupled receptors. It is mainly expressed in the nervous system and is linked to several neuronal signaling pathways; however, its role in neural development in vivo rem …