RAD51, a key component of the homologous recombination pathway, helps to stabilize DNA replication forks, repair the double strand break, and allow for the continuation of DNA …

In humans, RAD51 is a 339- amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair. In this repair process, an ATP …

Rad51 recombinase is a critical effector of homologous recombination, which is an essential DNA repair mechanism for double-strand breaks. Rad51 has been found to be upregulated in many …

Jan 1, 2017 · RAD51-dependent repair is essential for recovery from radiation and temozolomide-induced DNA damage. Targeting this pathway may provide a tumor cell-specific effect in the …

RAD51 is an ATPase that forms a nucleoprotein filament on single-stranded DNA. RAD51 has the function of finding and invading homologous DNA sequences to enable accurate and timely …

We review here the multiple levels of regulation of RAD51 expression and function and explore potential therapeutic leads. The RAD51 recombinase is a critical effector of Homologous …

Jun 2, 2022 · Background: Homologous recombination (HR) is an essential, high-fidelity mechanism to repair DNA double strand breaks (DSBs) in cancer cells. CYT-0851 inhibits HR …

Jul 2, 2020 · We show that RAD51 and other homologous recombination repair genes are overexpressed in metastatic melanoma cell lines and in melanoma patient samples, which …

RAD51 supports cell viability in vertebrates. Two-ended DSBs, such as those generated by ionising radiation, can be repaired by two major pathways: non-homologous end joining …

Jan 1, 2002 · To test whether Rad51 gene amplification causes up-regulation of Rad51 protein, we have visualized the Rad51 locus in eight representative tumor cell lines by metaphase FISH.