May 22, 2021 · MP NLS are a single cluster composed of 4–8 basic amino acids, which generally contains 4 or more positively charged residues, that is, arginine (R) or lysine (K). The …

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport. [1] Typically, this signal consists of one or …

We find that the PY-NLS-like sequence within Hrp1, which closely matches the PY-NLS consensus, is both necessary and sufficient for nuclear import and is also required for receptor …

Dec 11, 2020 · Remarkably, the structure reveals that the nuclear localization sequence of hnRNPA1 (termed PY-NLS), which is initially known to mediate the nucleo-cytoplamic …

Here, we show that Pab2 contains a proline-tyrosine nuclear localization signal (PY-NLS) that is necessary and sufficient for its nuclear localization and function. Consistent with the role of …

Many other types of NLS exist, e.g. the Proline-Tyrosine NLS (PY-NLS), named after the PY group in its motif: R/K/H-X (2–5) -P-Y (10). The classical NES motif contains three to four …

Sep 10, 2024 · The PY-NLS is a non-classical NLS characterized by 20–30 amino acids consisting of N-terminal hydrophobic or basic motifs and C-terminal R/K/H(X) 2-5 PY motifs …

Proteins destined for import into the nucleus contain nuclear localization signals (NLSs) that are recognized by import recep-tors termed karyopherins or importins. Until recently, the only …

May 9, 2008 · We find that the PY-NLS-like sequence within Hrp1, which closely matches the PY-NLS consensus, is both necessary and sufficient for nuclear import and is also required for …

Karyopherin-β2 or Transportin-1 binds proline-tyrosine nuclear localization signals (PY-NLSs) in its cargos. PY-NLSs are described by structural disorder, overall positive charge, and binding …